WARF: P99184US

Improved Liquid and Solid Tissue Mimicking Material for Ultrasound Phantoms


Ernest Madsen, Gary Frank

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method for making a liquid that mimics the ultrasonic propagation characteristics of human tissue.
OVERVIEWThe use of media that adequately mimic human tissue allows researchers to accurately determine exposure parameters by direct experimentation. These experiments will aid in the effort to limit patient exposure to ultrasound. Currently, the thermal index and mechanical index (two indicators for biological damage) are determined by assuming that the sound pulses in water and tissue are linear. However, this does not take into consideration that most ultrasound systems emit nonlinear pulses.
THE INVENTIONUW-Madison researchers have developed tissue-mimicking materials that can be used to determine exposure parameters more accurately. The tissue-mimicking material is composed of an ultrafiltered aqueous mixture of large, organic, water-soluble molecules in water, with a low concentration of lipids.
  • Measuring and calibrating the effects of ultrasound equipment on tissue
  • The tissue mimicking-material has speeds of sound and ultrasound attenuation that are the same as for human tissue.
  • The material is stable over extended periods of time.
  • The stability allows changes in a medical ultrasound unit to be determined over time.
  • The material can be made into a suitable form for determining the imaging characteristics of ultrasound scanners.
  • The tissue-mimicking material can be obtained commercially or produced by ultrafiltration of skim milk.
  • A solid tissue-mimicking material can be formed according to previous inventions that allows complex phantoms to be constructed (i.e., to simulate tumors).
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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