WARF: P02313US

Ultrasound Determination of Vascular Age


James Stein

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an improved method of determining an individual’s vascular age.
OVERVIEWCoronary heart disease is a leading cause of morbidity and mortality in the United States. A key challenge facing the cardiology community is the identification of high-risk individuals who would benefit from aggressive medical therapy. Traditional risk assessment models, such as the Framingham global risk assessment, fall short because they only estimate the short-term risk of coronary heart disease and not an individual’s overall risk.
THE INVENTIONA UW-Madison researcher has combined direct measurements of atherosclerotic burden with existing risk paradigms to determine an individual’s “vascular age.” Atherosclerotic burden is determined from measurements of carotid artery intimal-media thickness (CIMT) acquired by high-resolution ultrasound -- a non-invasive, highly reproducible technique for detecting and quantifying atherosclerosis. CIMT was combined with population-based nomograms from the Atherosclerosis Risk in Communities Study (1993. Stroke 24:1297-1304) to create mathematical algorithms for determining vascular age, which in turn is used in conjunction with traditional risk assessment models to improve evaluation of individual coronary heart disease risk.
  • Allows determination of an individual's vascular age
  • Promises to accurately identify high-risk individuals needing more aggressive medical therapy
For More Information About the Inventors
  • Stein J.H., Fraizer M.C., Aeschlimann S.E., Nelson-Worel J., McBride P.E. and Douglas P.S. 2004. Vascular Age: Integrating Carotid Intima-Media Thickness Measurements with Global Coronary Risk Assessment. Clin. Cardiol. 27, 388-392.
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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