WARF: P02279US

Method of Concentrating a Sample in a Microfluidic Device


David Beebe, Glenn Walker

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a simple system for concentrating a sample in a microfluidic device.
OVERVIEWMicrofluidic devices are being used in an increasing number of applications, including traditional laboratory tasks. To detect molecules in a small amount of solution, it’s often advantageous to first concentrate the sample; however, current methods of concentrating samples require complex microfabrication processing. In addition, the fluid sample often must carry an appropriate charge or the molecules in the fluid must be able to bind to a specific molecule.
THE INVENTIONUW-Madison researchers have developed a simple system, based on evaporation, to concentrate a sample in a microfluidic device. The system is composed of a channel within a microfluidic device, which includes a reservoir port and a collection port. The reservoir port can be any type of liquid/gas interface. The channel is filled with the solution that needs to be concentrated. As the solution evaporates from the collection port, the solution in the channel flows from the reservoir port to the collection port. The particles in the fluid concentrate at the collection port and are collected to obtain the concentrated sample.
  • Concentrating a sample to detect molecules in a small amount of solution
  • Inexpensive to implement
  • Works with any type of sample
  • Does not damage the particles in the solution to be sampled
  • Does not require surface treatment
  • Does not require complex system designs
  • Simple to incorporate into any microfluidic device design
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jeanine Burmania at or 608-960-9846.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.