New Patents

A Low-Cost, Dosimeter Accessory Kit Enabling the Collection of Accurate Sound Level Measurements from within the Ear Canal

Researchers from the University of Wisconsin – Whitewater in partnership with the Center for Device Design and Development at UW-Fox Valley, have developed a set of low-cost, dosimeter attachments that allow for sound levels to be measured in the ear canal. By combining these novel attachments with commercially available dosimeters, a more accurate reading can be obtained that reflects the true exposure level of potentially harmful noise to the individual. With the current accessory kit, one of three attachments comfortably fits in the user’s ear and connects to a standard dosimeter. Field tests have demonstrated that higher sound levels were recorded at the level of the ear canal using these attachments compared with the traditional method using a shoulder mounted dosimeter.
(Feb 11, 2020) T150024US02

Sharpening Filter for Orthovoltage Radiation

UW–Madison researchers have developed a compact filter that increases the sharpness of orthovoltage pencil beams and may be tailored to different beam sizes and focus depths.

The technology features a specially designed collimator and filter disk having concentric circular attenuation regions to produce the necessary sharpening effect. The flat design of the filter disk supports easy installation and replacement, and the concentric circular attenuation regions are amenable to computerized optimization of the region sizes and spacing.
(Jan 7, 2020) P170240US01

Medical Imaging with Better Temporal Fidelity Can Streamline Stroke Care

UW–Madison researchers have developed a method that increases temporal fidelity, sampling density and/or reduces noise of image frames obtained with a system such as CT, MRI or X-ray c-arm. After the images are acquired, a window function is selected and temporally deconvolves the image frames using a minimization technique. A temporal sampling density also may be selected and used in the temporal deconvolution.
(Dec 31, 2019) P130041US01

New Gradient-Based Cell Labeling Method Maintains Location Information During Downstream Analysis

UW–Madison researchers have developed a new device and method for tagging and monitoring individual cells in a microenvironment.

Concentrated dye solution is placed within molded wells inside a gel, diffusing throughout to form a color-based gradient. This stamp is then placed over the cell culture to be studied, allowing the dye particles to diffuse into the culture and label the cells. When the cells are removed from their environment for further analysis, the technique allows them to be easily identified and their previous location to be tracked.
(Dec 31, 2019) P150171US01

Method and Compounds for Treating Friedreich’s Ataxia

UW–Madison researchers have developed a chimeric synthetic molecule capable of inducing increases in FXN mRNA levels in Friedreich’s ataxia patient cell lines.

The complex has the formula A-L-B wherein A- is a bromodomain inhibitor, -L- is a linker, and -B is a polyamide that specifically binds to one or more repeats of a GAA oligonucleotide sequence. Mechanistically, when the complex binds to the repeat sequence, the bromodomain inhibitor (ex., Brd4) recruits the superelongation complex (SEC) to restart the paused transcription complex.
(Dec 31, 2019) P160232US05

Modified Yeast to Boost Biofuel Yields

A UW–Madison researcher has developed an S. cerevisiae strain that is 80 percent more effective at fermenting xylose. He discovered that knocking out several genes (hog1, isu1, gre3, ira1/2) enables dramatically faster xylose fermentation under the anaerobic conditions favored by industry.
(Dec 17, 2019) P140199US02

More Efficient Laminate Analysis

UW–Madison researchers have developed a method for analyzing composite laminate structures that combines the generality of 3-D FEA and efficiency of 2-D FEA whenever it is applicable. The new method works by substituting the laminate layers with much simpler virtual material models having matching characteristics (e.g., overall material properties and relationship between stresses and strains). The updated model can then by analyzed via fully automated 3-D FEA.

The virtual models may be referred to as ABD-equivalent models, as they result in the same ABD stiffness matrices as the real laminate and can act as substitutes if plate-shell assumptions apply.
(Dec 17, 2019) P140408US01

Analogs of Diptoindonesin G for Breast Cancer Drug Development

UW–Madison researchers have synthesized analogs of Dip G that have shown a greater ability than the parent molecule to decrease ERα expression and stabilize ERβ in cultured breast cancer cells. The compounds are active for ameliorating, attenuating and halting the growth/metastasis of breast cancers.
(Dec 17, 2019) P170010US02

Hormone Analogs for Treating Hypoparathyroidism

UW–Madison researchers have developed backbone-modified peptide analogs of PTH (1-34) that could be used to treat hypoparathyroidism, a condition caused by decreased gland function resulting in low blood calcium levels, abnormal muscle activity and other symptoms. The analogs were generated by replacing certain α-amino acid resides with β-amino acid residues.

The analogs were used to assess the impact of backbone modifications on receptor state-selectivity. The results show that diverse binding profiles can be achieved via this strategy and give rise to distinct behaviors in vivo.
(Dec 10, 2019) P130312US03