New Patents

Optimizing Nitrogen Use Efficiency in Dairy Cattle

A UW–Madison researcher has developed a simple algorithm to optimize nitrogen use efficiency based on values already measured in most dairy herds: milk urea-nitrogen yield (MUNY) and protein yield (PY) in milk. Once an ideal MUNY/PY ratio is identified through careful measurement, the value can be constantly monitored to determine if feed practices need to be adjusted. This kind of feedback can be provided within a day, unlike any other method.
(May 1, 2018) P140285US02

Tactile Button Panel for Use with Touch Screens

UW–Madison researchers have developed a touch screen system that attaches a simple button fixture over a portion of the screen. This is important because virtual ‘buttons’ may be difficult to see or manipulate.

The buttons have clear markings that can be felt by a user. When pressed, the buttons contact the touch screen and the task is performed as usual. The button panel may be mounted permanently or fastened.
(Apr 24, 2018) P110167US01

More Accurate Branch Predictor Circuit

UW–Madison researchers have developed a more accurate branch prediction method by distinguishing between ‘biased’ and ‘non-biased’ branch instructions. Biased branches are consistently skewed towards one direction while non-biased branches resolve in both directions.

The new method filters out biased branches because they merely reinforce earlier prediction decisions. Favoring non-biased branches enables more far apart correlations and superior prediction accuracy.
(Apr 24, 2018) P140330US01

Preen Oil: The Nutritional Approach to Chronic Inflammation

UW–Madison researchers have developed methods of using preen oil as a food supplement to treat chronic inflammation in human and non-human animals, birds and fish.

Preen oil may be given orally as a pharmaceutical composition, added to human food products or included in animal, bird or fish food. The fatty acids in the oil accumulate in tissues where they inhibit the pro-inflammatory cytokines IL-1 and IL-6 and reduce chronic inflammation, including chronic joint inflammation associated with rheumatoid arthritis and other diseases.
(Apr 17, 2018) P160017US01

Xenogen-Free Culture Medium for Stem Cells

UW–Madison researchers have developed a chemically defined, xenogen-free culture system for differentiating human pluripotent stem cells into mesoderm, endothelial and hematopoietic progenitor cells. The new culture system can be used to produce these types of cells from human pluripotent stem cells growing in completely defined E8 medium, thus providing an opportunity to manufacture clinical grade cells.

In the new method, the stem cells (human embryonic or human induced pluripotent stem cells) are seeded as a single cell suspension on a substrate comprising a layer of Tenascin C and IF9S culture medium supplemented with BMP4, Activin A, FGF2 and LiCl. The medium also comprises various hematopoietic cytokines. The stem cells are exposed to the mixture under hypoxic conditions for about two days.
(Apr 10, 2018) P130178US02

New Viral Propagation Method Yields Insight Into Childhood Asthma

UW–Madison researchers have developed an efficient, cost-effective method of propagating RV-C. They discovered that human cadherin-related family member 3 (CDHR3) is the receptor for RV-C and allows cell lines normally unsusceptible to HRV-C infection to support virus binding and replication.

To create cell lines capable of efficiently growing RV-C, the researchers modify the host cell so it expresses an effective amount of the CDHR3 receptor. This method enables high-throughput, large-scale production of RV-C, which in turn enables critical basic and applied research regarding this understudied pathogen.
(Apr 10, 2018) P140382US02

Combined Capacitor/Inductor with Improved Performance

UW–Madison researchers have now mitigated the problem of parasitic inductance. Their new design features a loop-back terminal structure that minimizes the net magnetic field induced by the capacitor current. In other words, the capacitor leads are routed back up through the middle of the core to cancel the increased inductance seen at the capacitor terminals.
(Apr 3, 2018) P150389US01

Rapid Three-Dimensional Elasticity Imaging

UW–Madison researchers have developed an ultrasonic probe assembly and a reconstruction technique for rapid three-dimensional elasticity imaging using limited data.

The probe sends an ultrasonic beam of energy into tissue and receives echoes from the displaced material generally along an axis. Ultrasound data is acquired over a set of planes (between four and six in number) angularly spaced and sharing a common axis. A computer receives the ultrasound data and determines elasticity of the material at multiple points within each plane. A three-dimensional reconstruction then is generated. This reconstruction is faster than the traditional sequential data acquisition for three-dimensional visualization.
(Mar 13, 2018) P130117US01

Improved Method to Produce Brain Microvascular Endothelial Cells for a Robust Human Blood-Brain Barrier Model

UW–Madison researchers have devised a novel method for reproducibly and efficiently growing human BMECs from human pluripotent stem cells (hPSCs), which include both induced pluripotent stem cells (IPSCs) and embryonic stem cells (ESCs). The BMECs have characteristic BBB properties, such as the expression of well-organized tight junctions and high transendothelial resistance. They can be used to create high-fidelity in vitro human BBB models.

The hPSCs are grown on a suitable matrix, such as Matrigel-coated plates, and subjected to an unconditioned medium. After several days, endothelial cell medium is added. Finally, other signals needed for further maturation of the BMECs are provided, and the cells are tested for BBB properties. Flow cytometry may be used to quantify cell development.
(Feb 27, 2018) P100219US02

New Electrostatic Motor Design Simplifies Manufacturing

UW–Madison researchers have developed a versatile design for large-scale electrostatic machines. The new design features circular rows of pegs attached to plates and immersed in dielectric fluid. The pegs come in and out of alignments as the plates rotate. The shape, length and positioning of the pegs can be varied as needed to achieve higher torque.
(Feb 20, 2018) P150105US01