Technologies
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WARF: P03315US

Antimicrobial Polymers


INVENTORS -

Samuel Gellman, Michael Gelman, Bernard Weisblum, David Lynn

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing novel amphiphilic compounds that could be used to treat microbial infections in humans and other animals.
OVERVIEWThe emergence of bacteria that are resistant to common therapeutic agents has resulted in a dire need for new antimicrobial compounds. One potential source of new antimicrobials is amphiphilic peptides, which contain both water-soluble and water-insoluble portions. These peptides act by disrupting bacterial membranes.
THE INVENTIONUW-Madison researchers have developed novel amphiphilic compounds that can be used to treat microbial infections in humans and other animals. They combined a synthetic backbone of poly(styrene), poly(acrylate), poly(acrylamide) or poly(C1-C6alkylene glycol) with side-chains that can readily accept a hydrogen atom to become water-soluble. These compounds inhibited the growth of four test microorganisms to the same extent as known antimicrobials.
APPLICATIONS
  • A new source of antimicrobial compounds that potentially could be used to treat microbial infections
  • Also promising as broad spectrum biocides and antiseptics, and for disinfecting and sterilizing surfaces
KEY BENEFITS
  • Production of amphiphilic compounds involves just one chemical synthesis step.
  • Effective against both Gram-positive and Gram-negative bacteria
ADDITIONAL INFORMATION
For More Information About the Inventors
Related Intellectual Property
Contact Information
For current licensing status, please contact Rafael Diaz at rdiaz@warf.org or 608-960-9847.
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UW–Madison has the integrative capabilities to complete many key components of the drug development cycle, from discovery through clinical trials. As one of the top research universities in the world, and one of the two best-funded universities for research in the country, UW–Madison offers state-of-the-art facilities unmatched by most public universities.

These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW–Madison with a complete translational research facility; and the innovative, interdisciplinary Wisconsin Institutes for Discovery, home to the private, nonprofit Morgridge Institute for Research and its public twin, WID, part of the university's graduate school. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.