WARF: P03366US

Cytomegalovirus Disintegrin-Like Peptides


Teresa Compton, Adam Feire

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing methods to inhibit the entry of viruses, such as herpesvirus, into host cells.
OVERVIEWAlthough human cytomegalovirus (HCMV) is capable of binding, penetrating, and initiating replication in all vertebrate cell types tested, the precise mechanism this virus uses to enter cells remains unknown. Integrins are cell surface receptors involved in the entry of many viruses into cells; however, HCMV does not contain any classic integrin-binding domains. One of the HCMV glycoproteins, glycoprotein B, plays a crucial role in attachment and fusion with the host cell.
THE INVENTIONUW-Madison researchers have developed methods to inhibit the entry of viruses, such as herpesvirus, into host cells, thus preventing viral infection. They identified a conserved integrin-binding, disintegrin-like domain in glycoprotein B that engages integrins and facilitates internalization of viruses into the host cell. Synthetic versions of this disintegrin-like peptide sequence, as well as antibodies against these sequences, block entry of HCMV into cells. They are potential antiviral agents for all members of the beta herpesvirus subfamily, including HCMV and human herpesvirus-6, which cause many chronic ailments and diseases.
  • Preventing or treating infection with HCMV, human herpesvirus-6, and other members of the beta herpesvirus subfamily
  • Studying integrins
  • May provide anti-cancer therapies
  • Provides the first known disintegrin-like domain involved in viral entry
Related Intellectual Property
Contact Information
For current licensing status, please contact Rafael Diaz at or 608-960-9847.
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