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WARF: P130007US02

Vitamin D Analogs “WT-51” and “WT-52” Boost Bone and Skin Health


INVENTORS -

Hector DeLuca, Lori Plum, Rafal Barycki, Margaret Clagett-Dame

The Wisconsin Alumni Research Foundation (WARF) is helping develop new 19-nor vitamin D compounds that are up to 10 times more potent in promoting cell differentiation.
OVERVIEWVitamin D (1,25-dihydroxyvitamin D3) is a highly potent regulator of calcium homeostasis and plays an established role in cellular differentiation. An important class of vitamin D analogs, the 19-nor-vitamin D compounds, shows high cell differentiation activity and minimal calcemic activity, making these analogs excellent candidates for a variety of pharmaceutical uses.
THE INVENTIONUW–Madison researchers have developed two new vitamin D3 analogs, (22E)-(24R/S)-2-methylene-22-dehydro-1α,24,25-trihydroxy-19-nor-vitamin D3, known as WT-51 and WT-52. These compounds show activity similar to that of the native hormone in stimulating intestinal calcium transport, but are up to 10 times more potent in promoting cell differentiation and gene transcription.
APPLICATIONS
  • Treating osteoporosis, osteomalacia and osteopenia
  • Improving bone strength and density
  • Treating skin issues such as psoriasis, wrinkles, dryness and acne
  • Potential anti-cancer agent, especially against leukemia, colon, breast and prostate cancers
  • Fighting obesity
  • Treating immune disorders in humans, including multiple sclerosis, lupus, diabetes mellitus, host-versus-graft reaction and organ transplant rejection
  • Treating inflammatory diseases such as rheumatoid arthritis, asthma and inflammatory bowel diseases
KEY BENEFITS
  • Extremely effective in increasing bone density without affecting serum calcium levels
  • Compound may be administered in many forms
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact John Nagel at jnagel@warf.org or 608-960-9848.
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