WARF: P120330US02

New Treatment for Restenosis


K. Craig Kent, Shakti Goel, Lianwang Guo

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method to treat blood vessel restenosis by applying a combination of insulin and connective tissue growth factor.
OVERVIEWAtherosclerosis (hardening of the arteries) is the leading cause of death in the United States. It can be addressed by several procedures, including angioplasty and bypass. However, when a blood vessel is injured during surgery, restenosis (narrowing of the vessel) can occur within a few months. Of the two million patients who undergo this surgery every year, restenosis occurs in up to 50 percent of cases.

Currently, restenosis is treated by a drug called rapamycin delivered through stents. Unfortunately, stents may cause more damage and prevent healing, leading to thrombosis. These drawbacks have driven the search for alternative anti-restenosis treatments.
THE INVENTIONUW–Madison researchers have developed an anti-restenosis formula made of insulin and connective tissue growth factor (CTGF). CTGF is a large protein known to help grow and remodel smooth vessel muscle after damage. The combination of CTGF and insulin increases levels of elastic collagen (type III) to promote healthy healing. The composition can be applied as an external wrap at the site of surgery.
  • More than 700,000 coronary artery bypass grafts are performed in the United States every year.
  • Preventing or reducing restenosis
  • Surgeries that could benefit from the new treatment include coronary artery bypass, endarterectomy, vein grafting and organ transplantation.
  • Promotes adaptive remodeling of blood vessels
  • Suppresses constriction and neointimal growth
  • Boosts levels of collagen III (elastic) relative to collagen I (rigid)
  • Easily applied as a perivascular wrap or patch
STAGE OF DEVELOPMENTThe combination of CTGF and insulin resulted in a significant synergistic increase in elastic collagen in rat aortic cells. Also, treated rat vessels showed an enlarged lumen area, increased external elastic lamina and decreased neointimal growth.
Contact Information
For current licensing status, please contact Andy DeTienne at or 608-960-9857.
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