Technologies
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WARF: P100078US02

Improved Production of Influenza Virus, Including H1N1, for Vaccine Manufacture


INVENTORS -

Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method and composition for improving production of vaccines against influenza viruses, including H1N1.
OVERVIEWThe H1N1 influenza virus, known as the “swine flu,” has been declared a pandemic.  While this virus is less virulent than many circulating strains of flu virus, it has become the subject of significant public health efforts, including international stockpiling of vaccine.  However, this virus is less amenable to high titer production than many of the more common influenza viruses, making vaccine manufacture challenging.
THE INVENTIONUW-Madison researchers have identified a single point mutation in the haemagglutinin (HA) gene of the H1N1 virus that enhances viral titer.  Introducing the mutation into vaccine seed viruses could lead to higher titer production of the viruses, improving vaccine manufacture.
APPLICATIONS
  • Production of H1N1 vaccine
  • Production of vaccines against other viruses
  • Viral mutagenesis studies
  • Identification of other HA mutations that alter growth of influenza virus
KEY BENEFITS
  • Significantly improves growth of influenza virus in cultured cells, including Vero cells
  • Enhances manufacturing of influenza vaccines, including vaccines against the H1N1 strain
  • Does not require helper virus
STAGE OF DEVELOPMENTThis mutation enhanced replication of H1N1 more than 1000 times in a cell line approved for human vaccine production.
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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UW–Madison has the integrative capabilities to complete many key components of the drug development cycle, from discovery through clinical trials. As one of the top research universities in the world, and one of the two best-funded universities for research in the country, UW–Madison offers state-of-the-art facilities unmatched by most public universities.

These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW–Madison with a complete translational research facility; and the innovative, interdisciplinary Wisconsin Institutes for Discovery, home to the private, nonprofit Morgridge Institute for Research and its public twin, WID, part of the university's graduate school. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.