Technologies
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WARF: P100077US02

Vitamin D Analog for Cancer Prevention and Treatment


INVENTORS -

Hector DeLuca, Katarzyna Barycka, Katarzyna Plonska-Ocypa, Rafal Barycki, Lori Plum, Margaret Clagett-Dame, Izabela Sibilska, Rafal Sicinski

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a vitamin D analog that is potentially useful as a chemotherapeutic agent.
OVERVIEWThe hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone mobilizes calcium from bones and increases intestinal absorption of dietary calcium. Effective therapeutic concentrations can lead to hypercalcemia; a condition characterized by elevated blood calcium levels, alterations in mental status, muscle weakness and calcification of soft tissues and organs such as the heart and kidneys. Therefore, a need exists for non-calcemic compounds that provide desirable therapeutic effects without causing dose-limiting hypercalcemia.
THE INVENTIONUW–Madison researchers have developed a novel vitamin D analog, (20S)-25-hydroxy-1-desoxy-2-methylene-19-nor-vitamin D3. This compound binds the vitamin D receptor and causes differentiation of cancer cells nearly as well as calcitriol but does not raise tissue calcium levels to the same degree, suggesting that it could be developed into a useful anticancer agent.
APPLICATIONS
  • Cancer prevention and treatment, particularly for leukemia, colon cancer, breast cancer, skin cancer or prostate cancer
KEY BENEFITS
  • Exhibits direct cellular activity in causing cell differentiation and gene transcription and in suppressing cell growth
  • Less likely to cause dose-limiting hypercalcemia than calcitriol
  • Can be administered in many forms
Contact Information
For current licensing status, please contact Rafael Diaz at rdiaz@warf.org or 608-960-9847.
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UW–Madison has the integrative capabilities to complete many key components of the drug development cycle, from discovery through clinical trials. As one of the top research universities in the world, and one of the two best-funded universities for research in the country, UW–Madison offers state-of-the-art facilities unmatched by most public universities.

These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW–Madison with a complete translational research facility; and the innovative, interdisciplinary Wisconsin Institutes for Discovery, home to the private, nonprofit Morgridge Institute for Research and its public twin, WID, part of the university's graduate school. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.