Technologies
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WARF: P04277US

In Vitro Differentiation of Neural Stem Cells and Neurons from Human Embryonic Stem Cells


INVENTORS -

Su-Chun Zhang, Xue-jun Li

The Wisconsin Alumni Research Foundation is seeking commercial partners interested in developing a simple and efficient method of differentiating human embryonic stem cells into neural stem cells and neurons.
OVERVIEWHuman embryonic stem (hES) cells have the potential to provide a source of specific cell types for research and ultimately, for therapeutic transplantation into humans.
THE INVENTIONUW-Madison researchers have developed a simple and efficient method of differentiating human embryonic stem cells into neural stem cells and neurons for pharmaceutical screening and potential transplant therapy. The system is easily standardized and completely chemically defined. First, hES cells are aggregated and treated with fibroblast growth factors to induce the cells’ development into early neural stem cells. Different combinations of growth factors are then used to direct these naïve neural stem cells to become progenitors of various types of neurons. The neural progenitors organize into neural tube-like rosettes that can be readily enriched and further differentiated into functional spinal motor neurons, midbrain dopaminergic neurons or forebrain dopaminergic neurons.
APPLICATIONS
  • Pharmaceutical and toxicological screening of a compound’s effect on neuronal development and function
  • Isolating a population of forebrain dopamine neurons, midbrain dopamine neurons or spinal motor neurons at specific developmental stages
KEY BENEFITS
  • Allows directed differentiation of hES cells toward a specialized neuronal fate in a standard culture system
Contact Information
For current licensing status, please contact Andy DeTienne at adetienne@warf.org or (608) 262-7859.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.