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WARF: P07197US

Automated Software System for Optimal Beam Setup in Radiation Cancer Therapy Systems


INVENTORS -

Robert Meyer, Leyuan Shi, Warren D'Souza

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing software that significantly improves the selection of the optimal beam angles to treat tumors with minimal exposure to surrounding healthy tissue.
OVERVIEWRadiation therapists must carefully determine beam angles and radiation dose to accurately target tumors while avoiding healthy tissue.  Of special importance are nearby organs-at-risk, which often are affected by particular radiation treatments. 

Currently, beam optimization relies on an estimate by an expert in the field to select an appropriate beam configuration. Intensity Modulated Radiation Therapy (IMRT) is a technique that uses highly precise external beams to optimize the radiation distribution to reduce exposure to healthy tissue. This method is vital in reducing adverse outcomes in patients with prostate cancer, primary brain tumors, metastatic brain tumors, head and neck cancers and other cancers with important surrounding tissue. While the system can significantly reduce treatment time, the use of multiple beam orientations and radiation blocking makes it extremely complex to configure.
THE INVENTIONUW-Madison researchers have developed software that uses iterative processes and parallel computing power to select the optimal beam setup to treat tumors while sparing surrounding tissue.  Therapists begin with an estimate of a dosage scheme, and the software computes the average dose that can be applied to each organ that may be at risk of radiation exposure.  Each organ is given an adjustable weight of its importance.  Based on those weights and potential beam configurations, the program uses nested partitioning—an industrial engineering technique that has never been applied to radiation treatment planning before—to evaluate each potential beam setup.
APPLICATIONS
  • Radiation treatment software
KEY BENEFITS
  • Selects optimal beam angles to treat tumors and spare healthy tissue
  • Offers significantly better treatment plans than experts can produce
  • High accuracy allows greater daily doses, reducing treatment time.
  • Can be used with any type of radiation treatment
  • May be implemented as an add-on to an existing planning system
  • Parallel computation accelerates the process.
  • High throughput computing system performs steps quickly.
  • Relative weights of organs-at-risk can be adjusted to give certain organs more or less value.
  • Reduces patient discomfort
  • Reduces time required to select appropriate treatment
  • Significantly reduces radiation delivered to non-cancerous organs-at-risk near tumors
ADDITIONAL INFORMATION
For More Information About the Inventors
Publications
  • D'Souza W., Zhang H., Nazareth D., Shi L. and Meyer R.R. 2008. A Nested Partitions Framework for Beam Angle Optimization in Intensity-Modulated Radiation Therapy. Phys. in Med. and Bio. 53, 3293-3307.
Contact Information
For current licensing status, please contact Jeanine Burmania at jeanine@warf.org or 608-960-9846.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.