Technologies
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WARF: P130267US02

Invertebrate Models for Studying Traumatic Brain Injury


INVENTORS -

David Wassarman, Barry Ganetzky

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in an in vivo screening method for identifying therapeutic agents to treat traumatic brain injury.
OVERVIEWEvery year about two million cases of traumatic brain injury (TBI) occur in the United States, caused by falls, car crashes, sports collisions and other injuries. TBI can lead to a host of health problems such as neurodegeneration, memory deficit and sleep disorder. The estimated cost of treatment and lost productivity due to TBI surpasses $76 billion in the U.S. alone.

Despite the urgent need for effective TBI treatments, none have been developed to date. Drug candidates tested in standard animal models (mostly rats and mice) have all failed in clinical trials. This failure is due in part to the complex nature of TBI as well as the brain’s elaborate response to injury.

Moreover, a significant disadvantage of using rodents is that they are unsuitable for high throughput drug screens, which could revolutionize TBI treatment.
THE INVENTIONUW–Madison researchers have developed a method for inflicting closed head TBI in invertebrates. The method can be used to screen candidate therapeutic agents for treating TBI.

Specifically, the researchers created a device that mechanically induces TBI in organisms such as Drosophila melanogaster (fruit flies), which respond to impact trauma in many of the same ways as humans. Subjecting these organisms to a controlled impact and dosing with test agents could help identify the biological pathways associated with the consequences of TBI as well as enable screens for therapeutic compounds.

The device consists of a spring attached to a vial containing up to 100 flies. The spring is pulled back and then released, striking the vial against a rubber pad to inflict brain trauma as the flies collide with the bottom and walls of the vial. The device can be adjusted to inflict injury at differing severities.
APPLICATIONS
  • Investigating closed head traumatic brain injury
  • Supporting technology for drug screening
KEY BENEFITS
  • Unique in vivo screening method
  • Offers new hope for treating TBI
  • Simple design, reproducible results
  • Enables new animal models for TBI research
  • Flies and worms are cheaper to raise and maintain than rodents, and lend themselves to high throughput screens.
STAGE OF DEVELOPMENTUsing their new device, the researchers have obtained preliminary data demonstrating that in flies, as in humans, TBI can cause lethality and neurodegeneration, activate the innate immune system and affect sleep patterns. Outcomes are dependent on age, genotype, impact severity and the interval between repetitive impacts.
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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These include the Small Molecule Screening Facility at the UW Comprehensive Cancer Center; the Zeeh Pharmaceutical Experiment Station, which provides consulting and laboratory services for developing formulations and studying solubility, stability and more; the Waisman Clinical Biomanufacturing Facility; the Wisconsin Institute for Medical Research, which provides UW–Madison with a complete translational research facility; and the innovative, interdisciplinary Wisconsin Institutes for Discovery, home to the private, nonprofit Morgridge Institute for Research and its public twin, WID, part of the university's graduate school. The highly qualified experts at these facilities are ready to work with you to create a library of candidates for drug development.