WARF: P08224US

  • Assigned to WARF as biological material.

Mouse Strains and Cells Useful to Investigate Tissue-Specific Roles of Stearoyl-CoA Desaturase Isoforms


James Ntambi

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing materials useful for the study of SCDs and their tissue-specific roles.
OVERVIEWStearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. SCDs may influence the development of diseases such as obesity, atherosclerosis and diabetes.
THE INVENTIONA UW–Madison researcher has developed several mouse strains and cells useful in the study of SCDs.  To understand the tissue-specific role of SCD1 and other SCD isoforms in disorders such as obesity, diabetes, cancer, inflammation, atherosclerosis and metabolism, the researcher generated mice with tissue-specific knockouts of SCDs.  He also developed transgenic mice in which SCDs can be overexpressed in specific tissues.
  • Studying SCDs and their tissue-specific roles 
  • Provides new tools for investigating the roles of SCD isoforms in various tissues
Contact Information
For current licensing status, please contact Rafael Diaz at or 608-960-9847.
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