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WARF: P04176US

  • Assigned to WARF as biological material.

Rat Strain Showing Developmental Changes in Alternative Splicing of the Heart Protein Titin


INVENTORS -

Marion Greaser, Chad Warren, Paul Krzesinski

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a mutant rat strain that shows an altered developmental pattern of titin expression.
OVERVIEWTitin is a very large cardiac protein that determines the resting tension of the heart in rats. Isoforms of titin are generated by alternative splicing of a single titin gene. Titin in embryonic rat hearts is 3.7 million Daltons in size; titin in adult hearts is 3.0 million Daltons; and several intermediate-sized titins are found in the hearts of rats between one- and 25-days old.
THE INVENTIONUW-Madison researchers have now discovered a mutant rat strain that shows an altered developmental pattern of titin expression. In these rats, the developmental transition in titin expression is dramatically retarded, so that titin in a 30-day old mutant rat is the same size as titin in a one-day old normal rat. These mutant animals should enable critical experiments to determine the effect of titin size on cardiac performance.
APPLICATIONS
  • Investigating the role of titin size in cardiac performance
KEY BENEFITS
  • Provides a useful model system for understanding the mechanisms controlling alternative splicing
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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