WARF: P04176US

  • Assigned to WARF as biological material.

Rat Strain Showing Developmental Changes in Alternative Splicing of the Heart Protein Titin


Marion Greaser, Chad Warren, Paul Krzesinski

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a mutant rat strain that shows an altered developmental pattern of titin expression.
OVERVIEWTitin is a very large cardiac protein that determines the resting tension of the heart in rats. Isoforms of titin are generated by alternative splicing of a single titin gene. Titin in embryonic rat hearts is 3.7 million Daltons in size; titin in adult hearts is 3.0 million Daltons; and several intermediate-sized titins are found in the hearts of rats between one- and 25-days old.
THE INVENTIONUW-Madison researchers have now discovered a mutant rat strain that shows an altered developmental pattern of titin expression. In these rats, the developmental transition in titin expression is dramatically retarded, so that titin in a 30-day old mutant rat is the same size as titin in a one-day old normal rat. These mutant animals should enable critical experiments to determine the effect of titin size on cardiac performance.
  • Investigating the role of titin size in cardiac performance
  • Provides a useful model system for understanding the mechanisms controlling alternative splicing
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at or 608-960-9854.
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