Technologies
PDF


WARF: P06475US

  • Assigned to WARF as biological material.

A Monoclonal Antibody Specific for Brain Alpha-Dystroglycan


INVENTORS -

James Ervasti, Erin McDearmon-Blondell, Ariana Combs

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing monoclonal antibody that specifically recognizes brain alpha-dystroglycan from a variety of species.
OVERVIEWThe transmembrane protein dystroglycan is associated with autosomal recessive muscular dystrophies. Although dystroglycan is glycosylated in a tissue-specific manner, no commercial monoclonal antibodies capable of differentiating between the various tissue-specific glycoforms of alpha-dystroglycan currently exist.
THE INVENTIONUW-Madison researchers have developed mAb 2238E2D2, an IgG2b isotype monoclonal antibody that specifically recognizes brain alpha-dystroglycan from a variety of species. They developed this monoclonal antibody by immunizing mice with purified alpha-dystroglycan from bovine brain and screening for antibodies that reacted only with brain alpha-dystroglycan. They also created another monoclonal antibody, mAb 2237E2D1, which is specific for brain alpha-dystrogylcan from cows.
APPLICATIONS
  • Research on dystroglycan and associated muscular dystrophies
KEY BENEFITS
  • Provides—for the first time—an antibody that recognizes alpha-dystroglycan in a tissue-specific manner
STAGE OF DEVELOPMENTSuccessfully used to identify brain alpha-dystroglycan in Western blot analysis.
ADDITIONAL INFORMATION
Publications
  • McDearmon E.L., Combs A.C., Sekiguchi A., Fujiwara H. and Servasti J. 2006. Brain a-Dystroglycan Displays Unique Glycoepitopes and Preferential Binding to Laminin-10/11. FEBS Letters. 580:3381-3385.
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
The WARF Advantage

Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.