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WARF: P06105US

  • Assigned to WARF as biological material.

Mouse Monoclonal Antibodies to the Human Nuclear Receptor, Estrogen-Related Receptor Alpha


INVENTORS -

Richard Burgess, Nancy Thompson, Jennifer Lamberski, Janet Mertz, Elizabeth Vu, Adebanke Lesi, Richard Kraus

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing high quality, well characterized monoclonal antibodies to ERRalpha.
OVERVIEWEstrogen-related receptor alpha (ERRalpha) is a recently discovered biomarker and treatment target for breast cancer (See WARF reference number P03031US). However, few, if any reliable monoclonal antibodies to ERRalpha are commercially available.
THE INVENTIONUW-Madison researchers have developed high quality, well characterized monoclonal antibodies to ERRalpha. Because some of these antibodies bind antigen tightly but release it when eluted with a mixture of salt and a polyol, they are ideal for use in immunoaffinity chromatography.
APPLICATIONS
  • Immunoprecipitations, including chromatin immunoprecipitation on arrays
  • Western blots
  • Immunoaffinity chromatography
  • Potentially useful as a cancer diagnostic tool or therapeutic drug
KEY BENEFITS
  • Some antibodies are useful for "supershifting" ERRalpha-DNA complexes during electrophoresis.
  • Those that are "polyol-responsive" are suitable for polyol-based purification of ERRalpha and associated proteins. 
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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