Technologies
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WARF: P07041US

  • Assigned to WARF as biological material.

Polyclonal Antibody That Recognizes the Sulfonylurea Receptor 1 Isoform


INVENTORS -

Jonathan Makielski, Nian-Qing Shi, Bin Ye

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing antibodies that specifically recognize sulfonylurea receptor isoforms and splice variants.
OVERVIEWSulfonylurea receptors (SURs) regulate the opening and closing of ATP-sensitive potassium channels (KATP). They play important roles in insulin secretion in the pancreas and myocardial protection in the heart. At least two isoforms of SUR exist, and the mRNA from each isoform can be spliced in different ways to result in further variants of SUR. The SUR1 isoform encodes the high-affinity sulfonylurea receptor, which is found in pancreatic beta-cells, while the SUR2 isoform encodes the low-affinity sulfonylurea receptor, which is mainly present in mitochondria-rich cardiac, smooth and skeletal muscles.

Antibodies would be a useful tool to further investigate SURs. However, commercially available antibodies do not distinguish between SUR variants. Additionally, available antibodies yield variable results and have not been rigorously tested for specificity.
THE INVENTIONUW-Madison researchers have developed an antibody, known as BNJ1, that specifically recognizes SUR1. It can be used in combination with other antibodies developed by the inventors (see WARF reference numbers P08021US, P08022US, P08023US and P08024US) to distinguish SUR isoforms and splice variants.
APPLICATIONS
  • Provides a useful tool for further investigating SURs
KEY BENEFITS
  • Tested for specificity in mouse heart, brain and liver cells, as well as dog and human heart cells
  • Affinity purified
STAGE OF DEVELOPMENTThis antibody was successfully tested against stable cell lines expressing KATP channels.
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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