WARF: P03206US

  • Assigned to WARF as biological material.

Cell Line Stably Expressing the Human Heart Sodium Channel Beta1 Subunit


Jonathan Makielski, Bin Ye, Carmen Valdivia

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in a stably transfected cell line expressing the beta1 subunit of the human heart sodium channel.
OVERVIEWThe human heart sodium channel beta1 subunit is a protein encoded by a single gene. It interacts with the alpha subunit to alter the functional properties of the channel.
THE INVENTIONUW-Madison researchers have developed a stably transfected cell line expressing the beta1 subunit of the human heart sodium channel. The beta1 subunit was first cloned in the early 1990s. The researchers have now re-cloned this subunit and created a cell line that permanently expresses it.
  • Drug testing and screening
  • Allows electrophysiological and pharmacological studies free from interference of other ion channels
  • Only an alpha subunit needs to be transiently transfected into this cell line to conduct experiments with the combined subunits, saving the trouble and expense of co-transfection with both subunits
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at or 608-960-9854.
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