Technologies
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WARF: P06061US

Using Stromal Collagen to Help Diagnose and Characterize Breast Cancer


INVENTORS -

Patricia Keely, Paolo Provenzano, John White, Kevin Eliceiri

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an imaging method that may assist in diagnosing cancerous and precancerous conditions in breast tissue.
OVERVIEWBiomedical imaging allows physicians to detect the onset of disease, injury and other disorders at an early stage, and to monitor their progression.
THE INVENTIONUW-Madison researchers have developed an imaging method that may assist in diagnosing cancerous and precancerous conditions in breast tissue. Because breast cancer is frequently associated with the increased deposition of proteins, particularly collagen, in the extracellular matrix, the inventors developed three tumor-associated collagen signatures, or TACS, which provide novel markers for localizing and characterizing breast tumors.

To identify breast carcinomas, nonlinear optical microscopy is used to generate high resolution, 3-D images of a test tissue. The images are then analyzed to detect and characterize any TACS that may exist in the tissue. The degree to which the TACS are present correlates with the onset and progression of cancer, thus providing diagnostic information complementary to conventional diagnostic methods.
APPLICATIONS
  • Breast cancer diagnosis
KEY BENEFITS
  • Provides reliable indicators to help identify and characterize breast tumors in animal models and human tissues
  • Enables clinicians to more effectively diagnose abnormal tissue
  • Facilitates therapy at an earlier stage
  • Test tissue may be a fresh, unfixed, unstained biopsy sample; an intact tissue in an organism; or a paraffin-embedded, sectioned biopsy or tissue sample.
  • Method is non-invasive and non-destructive
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jeanine Burmania at jeanine@warf.org or 608-960-9846.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.