WARF: P03381US

Mutated Tn5 Transposase Proteins and Their Uses


William Reznikoff, Richard Gradman

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing Tn5 transposase mutants with high transposase activity.
OVERVIEWThe low mobility of bacterial transposons, such as Tn5, makes it difficult for researchers to detail the molecular transposition process and to exploit transposition for uses such as the development of new diagnostic and therapeutic resources.
THE INVENTIONUW-Madison researchers have developed Tn5 transposase (Tnp) mutants with higher transposase activities than either wild-type Tnp or hyperactive Tnp mutants previously developed by the inventors. These new mutants are modified at several amino acids so that they have greater affinity for Tn5 end sequences than does wild-type Tnp.
  • A variety of in vitro and in vivo transposition applications
  • Show higher transposition rates than either wild-type transposase or a previous hyperactive mutant transposase
Contact Information
For current licensing status, please contact Jennifer Gottwald at or 608-960-9854.
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