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WARF: P06152US

Protein Inhibitor of Ran Activity


INVENTORS -

Ann Palmenberg, Frederick Porter, Christiane Wiese, Yury Bochkov

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a specific inhibitor of Ran activity.
OVERVIEWProteins and nucleic acids are actively transported in and out of the nucleus through nuclear pores. A small protein called Ran is the gatekeeper for large, complex pore structures.
THE INVENTIONUW-Madison researchers have identified a specific inhibitor of Ran activity. They discovered that the encephalomyocarditis virus leader protein, a small protein with no measurable enzymatic activity, binds directly and specifically to Ran. Expression of this leader protein in human cells inhibits Ran activity, blocking nuclear export of cellular mRNAs and leading to reduced translational activity.
APPLICATIONS
  • Studying nuclear transport, mitotic spindle assembly, inhibition of cellular translation or any other metabolic process that requires active cycling of Ran
KEY BENEFITS
  • Provides─for the first time─a specific inhibitor of Ran activity
ADDITIONAL INFORMATION
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at jennifer@warf.org or 608-960-9854.
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Since its founding in 1925 as the patenting and licensing organization for the University of Wisconsin-Madison, WARF has been working with business and industry to transform university research into products that benefit society. WARF intellectual property managers and licensing staff members are leaders in the field of university-based technology transfer. They are familiar with the intricacies of patenting, have worked with researchers in relevant disciplines, understand industries and markets, and have negotiated innovative licensing strategies to meet the individual needs of business clients.