WARF: P06152US

Protein Inhibitor of Ran Activity


Ann Palmenberg, Frederick Porter, Christiane Wiese, Yury Bochkov

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a specific inhibitor of Ran activity.
OVERVIEWProteins and nucleic acids are actively transported in and out of the nucleus through nuclear pores. A small protein called Ran is the gatekeeper for large, complex pore structures.
THE INVENTIONUW-Madison researchers have identified a specific inhibitor of Ran activity. They discovered that the encephalomyocarditis virus leader protein, a small protein with no measurable enzymatic activity, binds directly and specifically to Ran. Expression of this leader protein in human cells inhibits Ran activity, blocking nuclear export of cellular mRNAs and leading to reduced translational activity.
  • Studying nuclear transport, mitotic spindle assembly, inhibition of cellular translation or any other metabolic process that requires active cycling of Ran
  • Provides─for the first time─a specific inhibitor of Ran activity
For More Information About the Inventors
Contact Information
For current licensing status, please contact Jennifer Gottwald at or 608-960-9854.
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