WARF: P01120US

Method of Using Anti-Phospholipase A2 Antibodies to Reduce Gastric Inflammation in Animals


Mark Cook

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing a method that uses antibodies against phospholipase A2 to reduce gastric inflammation in animals.
OVERVIEWCurrently, there are several techniques for maintaining the health of food-producing animals, which in turn decreases cost and increases the animal's growth. One method involves adding ionophore antibiotics to animal feed. However, this is not desirable for animals raised for foods because antibiotic residues may remain in the food.
THE INVENTIONA UW-Madison researcher has developed a method for reducing gastric inflammation in animals to improve feeding efficiency and enhance animal growth. The method uses antibodies against phospholipase A2 to limit the production of lipid metabolites such as prostaglandin and leukotrien. This reduces gastrointestinal traumas and prevents further tissue damage, ultimately improving animal growth.
  • Reducing gastrointestinal inflammation
  • Reduces gastrointestinal inflammation and improves feeding efficiency without deleterious effects
  • Antibodies may be administered to counteract intestinal inflammatory problems that may arise from exposure to endotoxin or infectious agents, or Crohn's disease.
  • Can reduce inflammation and prevent further tissue damage due to colitis and necrosis
  • Reduces the high cost of feeding food-producing animals
  • Brings the broiler to market maturity faster
  • Potentially reduces or eliminates the need for standard nonsteroidal anti-inflammatory drugs,which cause ulcerogenic side effects
Contact Information
For current licensing status, please contact Emily Bauer at or (608) 262-8638.
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