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WARF: P02017US

Magnetic Resonance Angiography Using Floating Table Projection Imaging


INVENTORS -

Charles Mistretta

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing an improved technique for obtaining whole body MRA images as a patient is moved through the FOV of an MRI scanner.
OVERVIEWMagnetic resonance angiography (MRA) uses the magnetic resonance phenomenon in conjunction with a signal-enhancing contrast agent to provide images of blood vessels. MRA is a valuable, non-invasive screening tool for cardiovascular diseases; however, the small field of view (FOV) in MRA limits the volume of blood vessels that can be imaged during a scan. When diagnosis requires imaging of a large volume (such as in the lower extremities of the body) multiple scans must be performed, each requiring lengthy and expensive patient repositioning, preparatory scans and re-injection of contrast agent.
THE INVENTIONA UW-Madison researcher has developed an improved technique for obtaining whole body MRA images as a patient is moved through the FOV of an MRI scanner. As the patient travels through the scanner on a table moving at approximately the same speed as a bolus of contrast agent moving through the patient’s vasculature, image data are continuously acquired for each sub-region of the patient’s body. To offset the effects of table motion, each data set is phase corrected to a reference position. These data are then used to construct an image of each sub-region. To speed image capture while maintaining image quality, the invention employs Mistretta’s Vastly Undersampled Imaging with Projections (VIPR) technique (see link below) to acquire image data.
APPLICATIONS
  • MR imaging of blood vessels
KEY BENEFITS
  • Promises a whole-body imaging technique with the simplicity of CT, but with all the special contrast mechanisms available with MRI
  • By effectively combining data from a number of spatially-limited field of views (FOVs), could allow capture of whole-body MRI images using inexpensive, short-bore magnets
  • Makes use of projection reconstruction data acquisition, which provides time-resolved series of images with high spatial and temporal resolution (see below)
  • Eliminates need for the expensive and time-consuming patient and scanner re-adjustments required to acquire multiple FOVs during MRA
  • Acquires image data continuously as patient moves through scanner, allowing better timing of the scan to contrast agent movement than previous, “stop-and-go” whole-body MRI techniques
ADDITIONAL INFORMATION
For More Information About the Inventors
Tech Fields
Contact Information
For current licensing status, please contact Jeanine Burmania at jeanine@warf.org or 608-960-9846.
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