Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
2-methylene-19-nor Vitamin D2 Compounds
WARF: P02026US

Inventors: Hector DeLuca, Sumithra Gowlugari, Rafal Sicinski

The Invention
2-Methylene-19-nor-24(S) and 24(R) derivatives of 1α,25-dihydroxyvitamin D2 are disclosed. These compounds are characterized by minimal bone calcium mobilization activity and relatively high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment of diseases such as renal osteodystrophy, autoimmune diseases, and osteoporosis. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as anticancer agents and for use treating skin diseases such as psoriasis [Image Omitted]
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847