Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
2-methylene-19-nor-20(s)-1 Alpha-hydroxy-bis-homo-pregnacalciferol In Crystalline Form
WARF: P02175US

Inventors: Hector DeLuca, James Thoden, Hazel Holden, Margaret Clagett-Dame, Pawel Grzywacz, Sumithra Gowlugari


The Invention
A method of purifying 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacaciferol to obtain 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol in crystalline form. The method includes the steps of boiling a solvent such as acetone under inert atmosphere, dissolving a product containing 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol crystals, and recovering the 2-methylene-19-nor-20(S)-1α-hydroxy-bis-homo-pregnacalciferol crystals.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847

WARF