Drug Discovery & Development
Immortalized Cells from the Mouse Urogenital Sinus and Adult Mouse Prostate
Inventors: Wade Bushman
The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing mouse cell lines that recapitulate the normal genetic responses of the stromal cells of the urogenital sinus and prostate.
No well-characterized prostate stromal cell lines currently exist.
A UW-Madison researcher has developed biological material that includes immortalized murine mesenchymal cells from the urogenital sinus and stromal cells from the lobes of the adult prostate. The cells were isolated from the INK4A transgenic mouse, which lacks genes that normally enforce senescence. A construct that expresses lacZ was included in these cells to allow their identification when they are grafted into mouse tissues.
- A system for screening drugs to treat prostate cancer
- Novel targets for the design of drugs to treat prostate cancer
- Useful to examine the role of specific mesenchymal and stromal genes in regulation of prostate growth
- May enable the identification of specific genes activated in response to prostate tumor cell signals
Stage of Development
The researcher has shown that these cell lines recapitulate the normal genetic responses of the stromal cells of the urogenital sinus and prostate.