Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Synthesis Of A-ring Synthon Of 19-nor-1alpha,25-dihydroxyvitamin D3 From (d)-glucose
WARF: P04088US

Inventors: Hector DeLuca, Masato Shimizu, Sachiko Yamada

The Invention
The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847