Therapeutics & Vaccines
Synthesis Of A-ring Synthon Of 19-nor-1alpha,25-dihydroxyvitamin D3 From (d)-glucose
Inventors: Hector DeLuca, Masato Shimizu, Sachiko Yamada
The present invention provides a method for the synthesis of an A-ring synthon phosphine oxide used in the preparation of 19-nor vitamin D compounds, and to novel synthetic intermediates formed during the synthesis. The new method prepares the phosphine oxide from (D)-glucose.