Generation Of Mice Carrying A Genomic Alteration In The Polg Gene That Leads To Accelerated Aging
Inventors: Tomas Prolla, Gregory Kujoth
A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase gamma (PolG) gene, wherein the mutation leads to high levels of mutations in polymerase mtDNA.
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