Wisconsin Alumni Research Foundation

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Generation Of Mice Carrying A Genomic Alteration In The Polg Gene That Leads To Accelerated Aging
WARF: P04229US

Inventors: Tomas Prolla, Gregory Kujoth

The Invention
A mouse model for mammalian aging is disclosed. In one embodiment, the invention comprises a mouse having a genomic mutation in the exonuclease domain II (ExoII) of a mitochondrial DNA polymerase gamma (PolG) gene, wherein the mutation leads to high levels of mutations in polymerase mtDNA.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Mark Staudt at [javascript protected email address] or 608-960-9845