Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Improved Pharmaceutical Botulinum Toxin Compositions
WARF: P05057US

Inventors: Gary Borodic

The Invention
Botulinum toxin, a well know systemic poison, produces favorable therapeutic effect by virtue of regionally attaching to nerves within the myoneural junction and possibly other tissues in a target region of a particular tissue. The present invention provides compositions of botulinum toxin and a sequestration agent that increase sequestration and delivery of the botulinum toxin to neural and associated tissues, as compared with available formulations of botulinum toxins, and thereby produce a beneficial clinical effect. The sequestration agents of the present invention include proteins, lipids and carbohydrates. A preferred composition of the present invention comprises a botulinum toxin and an albumin. The present invention also provides methods of treating neuromuscular diseases and pain using the disclosed compositions and methods of making the disclosed compositions.
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857