Wisconsin Alumni Research Foundation

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Novel Poly(A) Polymerases that Interact with Nuclear Phosphoinositide Signaling Molecules
WARF: P07036US

Inventors: Richard Anderson, Chunhua Song, David Mellman, Michael Gonzalez, Christy Barlow

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing novel PAPs that interact with phosphoinositide signaling molecules.
Polyadenylation, the generation of a long string of adenosine (A) residues on the 3` terminus of an mRNA molecule, is an important post-transcriptional modification in eukaryotes. Carried out by poly(A) polymerases (PAPs), polyadenylation is required for export from the nucleus, message stability and translation into proteins of target mRNA molecules.
The Invention
UW-Madison researchers have identified novel PAPs that interact with phosphoinositide signaling molecules. These new PAPs, called phosphatidylinositol phosphate (PIP)-PAPs, provide a new nuclear regulatory mechanism, and therefore a new means of controlling and regulating protein expression. Unlike known PAPs, the activity of these PIP-PAPs may be directly modulated by components of phosphatidylinositol-based signaling pathways, which play crucial roles in the regulation of cell processes at the plasma membrane and in the nucleus.

The first of these PIP-PAPs to be identified is the Speckle Targeted PIP kinase alpha Regulated (Star)-PAP. Altering the expression of Star-PAP affects a set of over 300 genes, many of which encode proteins that are important in oxidative stress pathways that modulate diseases, including neuronal disease, cardiovascular disease, stroke and pulmonary disease.
  • May lead to new methods of diagnosing, preventing or treating disorders associated with PIP-PAP activity, such as Alzheimer’s disease, Parkinson’s disease, atherosclerosis, inflammatory bowel disease or septic shock
Key Benefits
  • Provides a novel enzyme for use in analyzing gene expression
  • Enables a new means of controlling transcription via polyadenylation in vitro and in vivo
  • Useful in cell differentiation studies
  • Provides a new drug target in the oncogenic, neuronal, pulmonary and cardiovascular pathways 
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847