Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Methods And Compositions For Phosphate Binding
WARF: P08110US

Inventors: Hector DeLuca, Katarzyna Barycka, Lori Plum, Julia Zella, Margaret Clagett-Dame

The Invention
The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administering to the patient an amount of a dendrimer composition effective to prevent absorption of substantial amounts of phosphate from the patient's GI tract. In a preferred version, a dose of between 2.5 and 15 grams per day is effective to prevent over 80% of phosphate present in the patient's GI tract from being absorbed. The dendrimer composition may comprise a hydrocitrate, hydrochloride, hydrobromide, hydroacetate or hydroanionic form.
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847