Wisconsin Alumni Research Foundation

Pharmaceuticals & Vitamin D
Pharmaceuticals Vitamin D
Vitamin D Analogs for Treating Bone Cancers and Diseases
WARF: P100358US03

Inventors: Hector DeLuca, Margaret Clagett-Dame, Lori Plum, Izabela Sibilska-Kaminski, Rafal Sicinski

The Wisconsin Alumni Research Foundation (WARF) is seeking commercial partners interested in developing vitamin D analogs with high calcemic activity that may be useful in as anti-cancer agents, especially in the treatment and prevention of osteosarcomas.
Overview
The hormonally active form of vitamin D, known as calcitriol or 1,25 dihydroxyvitamin D3, has shown promise for treating diseases ranging from osteoporosis to cancer to psoriasis. However, the hormone mobilizes calcium from bones and increases intestinal absorption of dietary calcium. Effective therapeutic concentrations can lead to hypercalcemia; a condition characterized by elevated blood calcium levels, alterations in mental status, muscle weakness and calcification of soft tissues and organs such as the heart and kidneys. Therefore, a need exists for new compounds that provide desirable therapeutic effects without causing dose-limiting hypercalcemia.
The Invention
UW–Madison researchers have developed vitamin D analogs,(20S)-3-desoxy-2-methylene-1a,25-diydroxy-19-nor-vitamin D3 and (20R)-3-desoxy-2-methylene-1a,25-diydroxy-19-nor-vitamin D3.These compounds exhibit promising anti-cancer activities: high receptor binding, and the arrest and induced-differentiation of proliferating cells. High calcemic mobilization suggests particular effectiveness in the treatment of bone diseases.
Applications
  • Therapy for bone diseases, osteoporosis and osteosarcoma
  • Prevention and treatment of leukemia, skin cancer, breast cancer, colon cancer and prostate cancer
Key Benefits
  • High bone calcium mobilization
  • Lower intestinal calcium transport activity
  • Can be administered in many forms
Additional Information
For More Information About the Inventors
For current licensing status, please contact Rafael Diaz at [javascript protected email address] or 608-960-9847

WARF