Therapeutics & Vaccines
Syndecan Peptides And Polypeptides As Inhibitors Of Vegfr2 And Vla-4
Inventors: Alan Rapraeger, Oisun Jung
Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of α4β1 integrin (also known as very late antigen-4, VLA-4), and can inhibit engagement of VLA-4 with vascular endothelial growth factor receptor-2 (VEGFR2), thereby preventing tumor cell growth and tissue invasion.
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