Wisconsin Alumni Research Foundation

Therapeutics & Vaccines
Therapeutics Vaccines
Syndecan Peptides And Polypeptides As Inhibitors Of Vegfr2 And Vla-4
WARF: P150222US02

Inventors: Alan Rapraeger, Oisun Jung

The Invention
Peptides derived from amino acid residues 210 to 240 of human syndecan 1 and methods of use of such peptides are described. These peptides can inhibit activation of α4β1 integrin (also known as very late antigen-4, VLA-4), and can inhibit engagement of VLA-4 with vascular endothelial growth factor receptor-2 (VEGFR2), thereby preventing tumor cell growth and tissue invasion.
Additional Information
For More Information About the Inventors
Related Intellectual Property
For current licensing status, please contact Andy DeTienne at [javascript protected email address] or 608-960-9857