Therapeutics & Vaccines
Influenza Virus Replication For Vaccine Development
Inventors: Yoshihiro Kawaoka, Gabriele Neumann, Jihui Ping
The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes internal genes from an influenza virus vaccine strain or isolate, e.g., one that is safe in humans, for instance, one that does not result in significant disease, that confer enhanced growth in cells in culture, such as MDCK cells, or in eggs.
Related Intellectual Property