DELIVERY OF BIOLOGICS VIA MINERAL CRYSTALS FOR REGENERATIVE MEDICINE APPLICATIONS
Inventors: William Murphy, Gianluca Fontana, Andrew Khalil, Jae Sung Lee
UW-Madison researchers have developed a nanocrystals capable of delivering biologic payloads. Exemplary payloads include nucleic acids, proteins, and peptides, all of which have shown promise as vaccines or therapeutics. The inventors identified nanocrystals having physical characteristics that enable stabilization of the biologic molecules. Stabilization occurs via incorporation, adsorption, or a combination thereof. The nanocrystals themselves can be synthesized from various biocompatible precursors, including CaCl2 and Ca(NO3)2, with their aforementioned properties being controlled by processing parameters, including temperature. Ultimately, these nanocrystalline materials could provide a desirable delivery vehicle for existing or future vaccines and therapeutics.
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