Therapeutics & Vaccines
Stereocomplex Of Oligolactic Acid Conjugates In Micelles For Improved Physical Stability And Enhanced Antitumor Efficacy
Inventors: Glen Kwon, Yu Tong (Tony) Tam
The present technology relates generally to oligolactic acid conjugates and stereocomplexes of cortjugates of gemcitabine and gemcitabine derivatives, micelle compositions containing such conjugates or stereocomplexes of cortjugates, and methods of preparing and using such compositions to treat various cancers. The oligolactic acid conjugates and stereocomplexes of conjugates may include oligolactic acid comprising 2 to 20 lactic acid subunits and may be attached through an amide linkage to the nitrogen of the 4(N) of the gemcitabine or gemcitabine derivative. Compositions comprising water and a micelle comprising a poly lactic acidcontaining polymer and the oligolactic acid conjugate or stereocomplex of conjugates may be readily prepared. Methods of inhibiting or killing cancer cells and treating gemcitabine sensitive cancers are also provided.
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