Therapeutics & Vaccines
USE OF TOLL-LIKE RECEPTOR 4 AGONISTS TO TREAT INFLAMMATION AND TISSUE INJURY
Inventors: Peiman Hematti, John Kink, Christian Capitini, Matthew Forsberg, Reinier Hernandez, Zachary Rosenkrans, Nicholas Hess
The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkyl glucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.