Drug Discovery & Development
ENGINEERED TRYPTOPHAN DECARBOXYLASES AND USES THEREOF FOR SYNTHESIZING TRYPTAMINE ANALOGS
Inventors: Andrew Buller, Allwin McDonald
UW-Madison researchers have identified several tryptophan decarboxylase (TDC) mutations for improving enzymatic activity towards substituted tryptamines. Having identified these mutations, the researchers generated RgnTDC mutants via heterologous expression, enabling efficient production of these mutants for use as biocatalysts at scale. Finally, the researchers established the utility of these mutations in multiple formats including, whole-cell, single-enzyme, and multi-enzyme cascades.
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