Therapeutics & Vaccines
Fusion Cytokine Compositions and Methods of Use Thereof
WARF: P230246US02
Inventors: Jacques Galipeau, Mahua Dey
The Invention
UW-Madison researchers have developed a glioblastoma cancer vaccine using primary tumor cells transfected with a genetic construct expressing a fusion of IL-7 and GM-CSF. The transfected cells are treated (irradiated) to make them non-replicating. The transformed cells possess antigenic tumor proteins as well as the cytokine fusion protein and are used as a cancer vaccine. When the researchers provided this vaccine to a glioblastoma mouse model, they found the vaccine generated durable long-term anti-tumor immunity specifically in aged mice.
Additional Information
For More Information About the Inventors
Tech Fields
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