Veterinary : Livestock


Potential for Vaccine Against Johne’s Disease

UW–Madison researchers have developed MAP strains with mutated global gene regulators (GGRs) that may be utilized in a vaccine against Johne’s disease.

GGRs are proteins needed for initiating RNA synthesis, for example, sigma factors and transcriptional regulators. By deleting, inactivating or reducing some key GGR sequences in MAP bacteria, non-virulent strains could be produced and administered to animals to confer immunity.

Vaccine Candidates Against Johne's Disease

A UW-Madison researcher has developed potential vaccine candidates for Johne’s disease. The disease is caused by the slow-growing bacterium Mycobacterium avium subspecies paratuberculosis, or M. paratuberculosis. The inventor identified several Mycobacterium strain-specific genes that may contribute to the pathogenicity of M. paratuberculosis. These genes could be used to design vaccines against pathogenic subspecies of M. avium, including M. paratuberculosis. In a recent study, vaccine preparations based on these sequences helped protect rodents against infection with M. paratuberculosis.

Method for Optimizing Health and Productivity of Milk Producing Animals

UW-Madison researchers have developed a means of evaluating management programs for transition cows. Their method uses objective measures of each individual’s previous lactation performance and current state to accurately predict the individual’s expected milk production at her first milk test date. A transition monitor value, known as the “Transition Cow Index” or “TCI,” is then calculated as the difference between actual and predicted milk production. The transition monitor can be utilized to evaluate and optimize the health and productivity of individuals and herds, and to make comparisons of transition programs within and among herds.

Plasmids Encoding Avian Influenza Genes

A UW-Madison researcher has developed plasmids encoding either the H3 N1 or the H5 N2 genes of avian influenza. These genes were cloned directly from viral isolates and are under the control of the pol II promoter.