In the Pipeline

The Wisconsin Alumni Research Foundation supports a pipeline of promising projects in an effort to accelerate the public benefits of technologies developed in university laboratories. The following list highlights the Accelerator Program's projects in medical devices, biopharmaceuticals, computer-related sciences and other fields.

PROJECT NAME PRINCIPAL INVESTIGATOR(S) PROJECT DESCRIPTION
Biopharmaceuticals
Endotoxin detection in biopharmaceutical production Nicholas Abbott This product addresses measurement of bacterial endotoxin in samples containing nucleic acid, particularly in the context of the preparation of biotherapeutics. | P09241US02
Targeting EP3 and GLP-1 as a novel diabetes therapeutic – Phase II Alan Attie A combination of a DPP4 inhibitor and an EP3 inhibitor normalizes the level of insulin secretion in diabetic patients who do not fully respond to a monotherapy of DPP4 inhibitors. | P110240US02
Read more about Alan Attie's research: Unpuzzling diabetes
Small molecule inhibitors of L-FABP for treating hypertriglyceridemia Alan Attie and
Mark Keller
The project focus is a drug target associated with elevated triglyceride levels (called liver fatty acid binding protein or L-FABP) and the potential to inhibit this protein to block the release of low density lipids from the liver into the blood stream, thus lowering elevated triglyceride levels. | P110006US01
4-HBR in models of cancer Margaret Clagett-Dame The therapeutic agent 4-hydroxybenzylretinone has been shown to destroy cultured mammary cell cancers and is undergoing further testing. | P05114US
Osteo-anabolic vitamin D analogs Hector DeLuca There is a renewed commercial interest in vitamin D analogs to treat osteoporosis in light of recent reports linking long-term use of commonly used osteoporosis medications with increased incidence of fractures. Under a phase I Accelerator Program grant, the DeLuca laboratory devised a new research test that identified several vitamin D analogs with significant bone building properties. The new grant will support the second phase of the project, which will encompass final in vitro testing, synthesis of study compounds and animal studies to confirm biologic properties.
Activation of cytotoxic T lymphocytes by blockade of BAFF receptor BR3 for cancer immunotherapy Peiman Hematti This project focuses on validating a new method for generating active T cells used in active cellular immunotherapy, CAR-T and other autologous therapeutic platforms.
Expression of botulinum toxins Eric Johnson The project involves development of highly purified strains of botulinum toxin as second- and third-generation treatments for neuromuscular disorders.
Anti-fungal drug discovery Bruce Klein This project focuses on the discovery and characterization of histidine kinase inhibitors that may prove effective in treating fungal infections. The compounds offer therapeutic benefits without the toxicity associated with conventional treatments.
Triolimus: A triple-drug nanomedicine for treating cancer Glen Kwon and
Kevin Kozak

This project is a novel, nontoxic nanoformulation of anti-cancer agents created by encapsulating paclitaxel, rapamycin and 17-AAG into PEG-b-PLA micelles, which can simultaneously deliver anti-cancer therapeutic agents with less toxicity than conventional therapies that are delivered sequentially. It's hoped that the ability to safely and simultaneously deliver multiple drugs to target several cancer-related pathways at one time will help overcome the problem of cancer recurrence commonly seen in patients with solid tumors. | P090383US03
Prostate cancer vaccine Doug McNeel

This project is a plasmid DNA vaccine for prostate cancer. The vaccine encodes the PAP tumor antigen and may be used to prevent or delay metastatic disease following removal of the primary tumor. | P05235US
Read more: Madison Vaccines expands series A to advance prostate cancer drugs 
Small inhibitors of PCSK9 secretion Weiping Tang

This project is aimed at synthesizing and testing small molecule inhibitors of the secretion of proprotein convertase subtilisin/kexin type 9 (PCSK9), an inhibitor that holds great potential for the treatment of hyperlipidemia in human patients. | P150023US03, P150140US02

Enhanced intranasal delivery of biologics Robert Thorne

This project offers the potential for an effective and convenient approach to administering therapeutics to cross the blood-brain barrier. | P120322US02

Clean Technology
Volatile organic compound detector based on blue phase liquid crystals Nicholas Abbott This project involves the development of portable/handheld sensors for volatile organic compounds to potentially contribute to a safer home and work place environment. | P150037US02
Nanomechanical energy scavengers Robert Blick This project focuses on the development of a prototype device to capture waste heat from mobile computing devices and convert the heat to electricity. The prototype, a postage stamp-sized patch called a rectenna, is designed to adhere to a heat-generating device such as a mobile computer chip set. Tiny, oscillating pillars on the patch are able to receive waste energy from a variety of sources and convert it into direct current, creating a voltage source capable of charging the battery of the mobile computing device. | P100171US01
Developing new types of desalination cells using bismuth as a CI-storage electrode Kyoung-Shin Choi With much of the world experiencing fresh water scarcity, it is important to develop new ways of obtaining potable water. This project will work toward developing a practical desalination battery prototype using a novel chloride storage electrode. The prototype will have the ability to remove salt from water while using dramatically less energy than currently existing solutions. | P170083US01
Scale-up of GVL-based process for integrated production of sugars and lignin from biomass James Dumesic This project will focus on scale-up and optimization of a new method of obtaining sugars and lignin from biomass using recycled GVL. | P130123US01
Read more: Renewable chemical ready for biofuels scale-up
Strategic evaluation of new biomass conversion project James Dumesic,
David Alonso and
Stephanie Wettstein
Accelerator Program funds are being used for consulting and strategic market analysis on behalf of a new process to convert cellulosic waste into useful fuels and solvents. The process uses a catalyst to improve energy efficiency, reduce costs and minimize the use of corrosive chemicals compared with other methods for biofuels production. | P120195US01
Enhanced biomass digestion with wood wasp bacteria Brian Fox and
Cameron Currie
This project involves the development and optimization of reagents based on a Streptomyces secretome for deconstruction of plant biomass. | P110314US03
Cellulose nanofibril (CNF)-based aerogels as superabsorbents Shaoqin “Sarah” Gong This project focuses on the development of a CNF-based aerogel produced using an environmentally friendly freeze-drying process, with superior absorbency for various oils and organic solvents in water or on land. | P140038US02, P120283US03
Read more about cellulose nanofibrils: Nano from the forest
Heterogeneous catalysts for the oxidative dehydrogenation of alkanes Ive Hermans This project concerns the development of heterogeneous catalytic systems for the oxidative dehydrogenation of small alkanes as a route to produce olefins, as well as closely related oxidation chemistry. | P150387US02
Learn more about this technology: Novel catalysts improve path to more sustainable plastics production
Read the Science paper: Selective oxidative dehydrogenation of propane to propene using boron nitride catalysts
Scale-up of a renewable process for 1, 5-pentanediol production George Huber Bio-based polyol 1,5-pentanediol could be used in place of other petroleum-based polyols in paints, coatings and adhesives. Prof. Huber’s group has devised a simple, effective process to produce 1,5-PDO from bio-based furfural. In this project, they will optimize the process with different furfural feedstocks and industrially relevant catalysts as well as scale up the process to produce 1,5-PDO for industry evaluation. | P160103US01
Scalable, continuous processing of concentrated lignocellulosic biomass Daniel Klingenberg This project focuses on the production of biorenewable sugars and other chemicals. | P130123US01, P130272US01
Fabrication of slippery anti-fouling coatings on flexible catheters David Lynn This project seeks to advance the fabrication of a new class of ‘slippery’ polymer coatings with advanced anti-fouling and anti-microbial properties on the surfaces of flexible tubing commonly used to manufacture indwelling catheters. The project's broad goal is to prevent colonization and biofilm formation and reduce systemic infections caused by microbial pathogens more effectively than conventional materials or technologies. | P150342US02
Molecular separations membranes from Gemini surfactant lyotropic self-assembly Mahesh Mahanthappa The goals of this project are to cast thin, cross-linked lyotropic liquid crystals into thin film composite membranes and demonstrate their suitability for ultrafiltration applications. | P120009US01
Production of high-concentration sugars directly from lignocellulose Xuejun Pan This project will focus on development and demonstration of an innovative chemical process for producing high-concentration sugars from lignocellulosic biomass such as corn stover, switchgrass, hardwood and softwood in a short time and under mild conditions. These sugars will be suitable as a feedstock for the production of clean fuels and chemicals.| P110209US02
Technological and economic analysis of biomass deconstruction methods Ron Raines,
Joe Binder and
Christos Maravelias
The project involved process engineering analysis as well as examination of the technological and economic aspects of new biomass deconstruction techniques. The work highlighted the importance of recovering ionic liquid solvent from the process and results were presented at the WARF Biofuel Venture Capital Showcase in 2010. | P09305US02, P08210US
Creating a pulping model for zip-lignin trees Troy Runge and John Ralph This project focuses on altering the composition and structure of lignin via plant engineering to address biomass conversion recalcitrance problem, inherent in dealing with lignified plant cell walls. | P100225US02, P100281US02, P100281US03
Flow cathode with organic mediators for fuel cells Shannon Stahl Accelerator support will enable construction of a demonstration reactor for large-scale validation and optimization of a new type of fuel cell that uses a soluble molecular mediator/catalyst mixture rather than an expensive platinum catalyst. 
Lactobacillus casei ethanologen as an adjunct culture for the control of lactobacilli in ethanol fermentation facilities James Steele This project will support research to control harmful lactate production in bioethanol plants by developing Lactobacillus casei strains engineered to produce ethanol rather than lactic acid. | P130023US02
Novel injection molding processes for lightweight foamed parts Lih-Sheng (Tom) Turng This project aims to accelerate the commercialization of novel microcellular injection molding processing technology developed at UW–Madison for the mass production of lightweight, foamed parts with a high quality surface in a cost-effective fashion without the need for expensive capital investment. | P100252WO01, P110013US01
Three-dimensional nanowire electrode networks Xudong Wang The project involves development of an electrode designed to improve the performance of photoelectrochemical and photovoltaic cells for use in solar energy harvesting and conversion. The electrode incorporates a network of three-dimensional nanowire structures to maximize the overall surface area and enhance charge transport. The increased surface area captures more light, while the advanced chemical composition of the nanowires expands the spectrum of light that can be captured. A separate application of the electrodes involves photoelectrochemical reactions such as water splitting, which may be used to create hydrogen for long-term storage. | P110104US01
Computer Science and Engineering
SmartRE Srinivasa Aditya Akella These network-wide architecture and algorithm improvements are designed to minimize redundant content in a network, enabling network infrastructure as a whole to operate more efficiently. | P09290US
Read more about Aditya Akella's research: Computer sciences’ Akella makes networks ‘future-proof'
Virtual network services in the cloud Srinivasa Aditya Akella Stratos provides a framework for building a rich scalable virtual topology (e.g., a middlebox) to enable applications for enhanced cloud computing, virtual network services and software-defined networking. | P120286US01
Improving performance, availability and usability in OpenNF Srinivasa Aditya Akella OpenNF provides fast and correct reallocation of in-progress network flows. It provides a novel state transfer mechanism that allows fine-grained redistribution of traffic flows and optional guarantees for loss-free and order-preserving moves. It also delivers interoperability with existing SDN platforms and network functions via the use of an API. | P150073US01
Commercialization of semiconducting graphene (phase I) Mike Arnold and
Padma Gopalan
This project seeks to develop a commercially viable method of using graphene as a replacement for silicon and other materials currently used in semiconductors. Graphene, a thin layer of bonded carbon atoms, offers significant potential advantages over conventional semiconductor materials, including increased electron mobility and switching speed. This is phase one of four. | P100012US02
Read more: Graphene nanoribbon finding could lead to faster, more efficient electronics
Commercialization of carbon nanotube devices Mike Arnold and
Padma Gopalan
This project involves the development of semiconductor materials based on carbon nanotubes with attractive properties for high performance electronics.
Read more: Carbon nanotube finding could lead to flexible electronics with longer battery life
Read more: Carbon nanotube outperforms silicon
WiRover Suman Banerjee This system provides continuous, secure Internet capability in moving vehicles by managing and integrating multiple concurrent network connections, including WiFi, 3G cellular and satellite systems. | P100120US02, P100121US02
Super-resolving direction finding and geo-locating system Nader Behdad The objective of this project is to develop a super-resolving direction finding and geo-locating system capable of accurately determining its location (coordinates) with very high resolution in a manner similar to what is done with GPS receivers. However, unlike GPS, the device can be used for localization, positioning and navigation in indoor environments rather than being limited to outdoor use. | P110043US01, P120184US01
High-efficiency semiconductor lasers (phase I) Dan Botez and
Luke Mawst
This project involves development of a new generation of quantum cascade lasers with greater output, increased efficiency, improved heat dissipation, higher reliability and longer operating lives than conventional quantum cascade lasers. Potential applications would include laser marking of plastics, mid-infrared absorption spectroscopy, atmospheric signal transmission, chemical detection and directed infrared countermeasures. This is phase one of two. | P100284US01
Chemistry to enable nanopatterning of electronically active materials Padma Gopalan Self-assembly of block copolymers (BCPs) in thin films provides a large-area, high throughput route to creating dense nanostructures in length scales not easily achievable by traditional lithography processes. This project is focused on the development of new materials that will provide the performance required for BCP lithography and can be removed under milder conditions more suitable for advanced applications. | P100296US02, P09005US
Deep learning accelerator in the cloud Jing Li This project features a novel computer architecture for matrix calculations that will have significantly improved computational throughput, energy efficiency and performance density as compared to CPU, GPU and other FPGA-based implementations for deep learning. The enhanced speed of this specialized matrix accelerator will facilitate more interesting and interactive intelligent applications. And, the improved computational throughput will enable efficient inference across many applications (text, image, voice, video, etc.) using much larger neural networks with higher accuracy.
Integrated LC filters for grid tied inverters
Daniel Ludois The project seeks to build an optimized, commercially viable inductance-capacitance filter (referred to by industry as an LC filter) in the form of a single element combining the inductor and capacitor for testing in a grid tied inverter application. LC filters help smooth and "clean up" the power from the power supply to the power grid. This technology will allow power electronic circuits to become more power dense and cost efficient by integrating the components together, i.e., passive components up to 50 percent smaller and significantly lighter, which are benefits of critical importance in the automotive, aerospace and renewable energy industries. | P140216US01
Practical compact VCSEL on Si CMOS Zhenqiang (Jack) Ma The objective of this project is to accelerate the development of a commercially practical laser source on silicon (Si), with the demonstration of high performance ultra‐compact electrically‐pumped infrared laser prototype at 1550 nm band. | P08398US
Prototyping blue LEDs with high-efficiency hole injectors for commercialization Zhenqiang (Jack) Ma This project involves a multiple quantum well light emitting device, which provides a current tunneling layer for electrons and holes comprised of non-metal inorganic materials that allow the passage of holes from a first layer to a second layer in a lattice mismatched heterogeneous junction.

An approach for encrypting IP cores with simulation capability

Parmesh Ramanathan
(Kewal Saluja)

This project will further develop an encryption method whereby an IP Core [a logic circuit] is encrypted such that the structural information of the design is preserved but the gate/component functionalities are encrypted. The encryption is such that a designer can perform logic and fault simulation on the encrypted circuit without deducing the gate/component functionalities within the circuit. | P140095US01

PLUG Karthikeyan (Karu) Sankaralingam This is a chip for high-end network routers that employs smart software and flexible high-performance architecture to replace multiple special purpose components used to perform lookup functions for packet processing. | P09094US
Memory processing unit comprised of 3-D memory and simple cores Karthikeyan (Karu) Sankaralingam The goal of this hardware architecture project is to build a faster than real-time speech recognition chip called a memory processing unit. | P140414US01
CAP-MIMO Akbar Sayeed and
Nader Behdad
This is a design for a hybrid analog-digital wireless transceiver to deliver increased data capacity, higher power and bandwidth efficiency in a variety of applications. | P06176US, P110040US01
High performance cooling modules Timothy Shedd The project involves 3-D prototype production of high performance cooling modules that can be used to cool integrated circuits. The closed-system modules are designed to contain fluids that can be circulated over heat generating components in computers and other devices. | P04140US, P110174US01
Read more about the startup company formed in 2013 to commercialize this technology: Ebullient heats up with $1M for computer cooling tech
Fast, meshless simulation through dual representations Krishnan Suresh The project involves development of smart and efficient simulation software for analyzing thin components, with applications ranging from mechanical chassis to orthopedic surgical implants. The software provides rapid feedback to design engineers without the hassle of laborious finite element analysis and can be interfaced with numerous CAD packages including SolidWorks and Google Sketchup. | P08425US
Fiber power boards for mechanical energy harvesting from foot traffic Xudong Wang This project combines fiber-based triboelectric nanogenerator (TENG) technology with recycled natural materials like wood pulp and cardboard fibers to create mechanical energy harvesting floor material. Footfalls on this material generate an appreciable amount of electricity that can be harnessed for use. Under heavy foot traffic, the potential for high power output and energy conversion efficiency make these flooring products feasible as an eco-friendly, efficient and affordable technology for green building and infrastructure. | P160323US01
LiTell: Robust indoor localization using unmodified light fixtures Xinyu Zhang LiTell is an indoor localization technology that uses existing fluorescent and LED lights as location landmarks. It is deployable to existing infrastructure and provides accuracy to within 10 centimeters. LiTell will enable location-based services for all types of indoor venues, including novel applications for the retail industry, social networks, factory supply chains and public exhibition venues.
Food and Agriculture
Substituted chitin oligomers for use in promoting plant development Jean-Michel Ane This project will establish whether substituted short chitin oligomers (COs) provide a greater benefit to plants than simple unsubstituted short chitin oligomers by developing an improved method to purify COs from bacteria, improved stability metrics for the different CO structures, and specific CO structures and concentrations that elicit the most favorable responses from the tested plant species under controlled conditions.
Immunoassay for diagnosis of bovine paratuberculosis Michael Collins This project involves the comparison of a prototype assay developed by the investigator and commercial products using a validated sample bank.
Use of IL-10 antibodies to control parasites in cattle and poultry Mark Cook This project focuses on an antibiotic-free method to reduce parasite load and resistance in cattle and poultry. | P120128US01
Cosajaba oil as a growth-promoting, survival-enhancing feed ingredient in high value fish species Mark Cook, Terence Barry This poultry byproduct has anti-inflammatory properties and can be used in animal feed as a growth promoter. Results were particularly noticeable in fish, promoting growth and seeming to make the fish more tolerant to environmental stress. | P160017US01
Optimization of the process for the removal of phospholipids and off-flavors from soy protein isolate Srinivasan Damodaran While being a rich source of protein, soy products often impart "beany" or "grassy" off-flavors into commercial food products. Currently many companies mask these off-flavors or do not use soy protein additives for sensitive products. This work will develop and refine a method that removes the suspected source of these off-flavors. | P090393US02
Charged ultrafiltration membranes for changing the way food proteins are manufactured Mark R. Etzel This project is designed to validate a new charged membrane filter technology that allows for larger pore sizes to be used while still achieving equivalent separation due to electrostatic repulsion forces. These larger pore sizes allow for greatly reduced fouling, increased throughput and reduced cost and operational changeover/maintenance.
Hyperspectral reflectance-based models for early disease detection in potato Amanda Gevens This project will result in an algorithm for pre-symptomatic late blight disease detection validated on the two most economically important hosts of the late blight pathogen, potato and tomato, at multiple detection scales (direct plant, UAV-mounted, low altitude aircraft-mounted). This technology has the potential to revolutionize disease management and grower decision making, as well as long-term crop commodity modeling.
Improved methods and validation for next-generation diagnostics Tony Goldberg and
Kathy Toohey-Kurth
This project involves optimizing a method of using next-generation sequencing to diagnose microbial food contaminates in food and related products.
Rapid and visible detection of indicator organisms Sundaram Gunasekaran This project features a rapid and accurate immunoassay that will enable detection of microorganisms that signal contamination of food and water. | P100326US02
Insoluble and dispersible protein and dye-containing particles for use as colorants Richard Hartel This project involves further development of a technology that improves binding of colorants to protein particles and biologically inactive yeast to produce a novel group of safe organic pigments for food, cosmetic and pharmaceutical applications.
Modulation of NADPH oxidases to confer biotic and abiotic stress tolerance in soybean Mehdi Kabbage The researchers have identified genes in soybeans that confer tolerance to drought and Sclerotinia stem rot. Through this project, they will develop and test transgenic varieties with enhanced tolerance.
Use of sugary enhancer to improve vegetable production Shawn Kaeppler This project utilizes a newly discovered gene to enable development of new sweet corn varieties, as well as other vegetable and grain varieties for human consumption.
Scale-up of protein conjugates John Lucey and
Michael Molitor
This project further develops a novel, more cost-effective method of producing protein-polysaccharide conjugates (PPCs). PPCs improve the water solubility, pH, heat stability and emulsification of proteins, and among other uses, provide a substitute for gum arabic in the foods and beverage industry. | P08190US
Does dietary glycomacropeptide (GMP) burn body fat and increase bone strength in female mice fed an obesigenic diet? Denise Ney and
James Ntambi
This project focuses on a protein isolated from cheese whey that can be made into acceptable high-protein, low-calorie foods and beverages, which will promote satiety and thus reduce the desire to overeat. | P110272US03
Means for the control of storage browning in cheese Scott Rankin This project involves the identification of chemical and biological methods for preventing the undesirable browning of cheeses such as Parmesan. | P130152US01
Use of phospholipase A2 to inhibit oxidative rancidity in mechanically separated turkey (MST) Mark Richards Lipid oxidation can cause off-color and quality deterioration in meat, poultry and fish. The ultimate goal of this project is to provide a solution that addresses these issues in a cost-effective and process-compatible manner. Specific aims of this proposal include demonstrating the effectiveness of adding PLA2 to mechanically separated turkey (MST) and establish the purity and concentration of this reagent.
Stabilizing color during storage of meat substitutes that contain plant hemoglobin Mark Richards This project examines different strategies to stabilize color and lipid oxidation of plant-based meat substitutes.
Use of anti-IL-10 antibodies to control respiratory disease in growing livestock Daniel Schaefer and
Mark Cook

This project focuses on an antibiotic-free method to reduce bovine respiratory disease in cattle while increasing feed efficiency. | P120128US01

Release of 'Dane' soybean: A non-GMO, food-grade soybean for the upper Midwest Damon Smith This project features a food-grade, non-GMO soybean with white mold resistance and excellent protein and oil content.

Biomarkers for early diagnosis and differentiation of mycobacterial infections

Adel Talaat Professor Talaat is developing a diagnostic test that detects infection in dairy cattle with Mycobacterium avium paratuberculoisis (MAP, the causative agent of Johne’s disease) prior to the onset of any detectable signs or symptoms of the disease. | P150020US02 

Rational redesign of phytochromes for agricultural benefit

Richard Vierstra Phytochromes are a family of regulators that control the response of plants to light. Modification of these receptors should enable strains that will provide favorable properties important for increasing agricultural productivity.
Establishment and evaluation of Sundance and AG-X1 cranberry varieties Eric Zeldin and
Brent McCown
Two new cranberry varieties with superior yield, berry size and color traits are being trialed in Nova Scotia. | P100154US01
Medical Devices and In Vitro Diagnostics
Rapid preparation of
nucleic acid samples
David Beebe This new method of preparing nucleic acid samples decreases the preparation time from 30 minutes to 10 seconds and provides equal or enhanced performance. | P100050US01
Minimally invasive microwave ablation technology for targeted cancer treatment Nader Behdad and
Susan Hagness
This project focuses on novel microwave antenna designs for improved delivery of energy to tumors during ablation procedures. | P140132US01
Improving efficiency and accuracy for a novel stereotactic radiosurgery collimation device Edward Bender This project features an improved waveguide to enable better sparing of nearby brain tissue during stereotactic radiosurgery procedures. | P130196US01
A prospective pilot study with data collection and analysis of ultrasound and physiological respiratory data Guelay Bilen-Rosas,
Humberto Rosas and
Irene Ong
Airway obstruction during sedation causes reduced oxygen supply, which can lead to cardiac arrest, brain damage or even death. Current technology for monitoring the airway during sedation, like pulse-oximetry, is erroneous and not capable of detecting early airway obstruction. This project will include a pilot study and further development of software and hardware for an ultrasound-based, non-invasive, real-time monitor that displays information about the ever-changing respiratory mechanics during the various stages of sedation.
Mass spectrometry Robert Blick This new mass spectrometry detector will enable more accurate analysis of proteins and peptides. | P05110US, P09192US
Empowering imaged guided procedures by enabling the surgeon in the MR suite Walter Block

This project involves MRI imaging techniques to improve imaging frame rates and provide real-time MRI guidance to interventional procedures. | P08308US
Read More: University spinoff aims to hit the mark precisely with brain-scanning tool.

Modular multisource electron beam scanner for 3-D printing applications – Phase II Kevin Eliceiri and
Thomas (Rock) Mackie
A previous Accelerator project developed a modular linear multisource X-ray tube that would enable improved resolution for CT scans as well as the potential for metal 3-D printing in medical applications. This is a continuation on that project, finishing the prototype development of a next generation high-speed 3-D metal printer and demonstrating that a multisource electron beam design is capable of melting metal powder. | P140374US01
Polymer coatings for biofunctionalization Padma Gopalan and
William Murphy
This project features a polymer coating that can provide a chemically defined platform, is stable in a cell culture medium for over two months, can present stable peptides via a unique conjugation chemistry and can be tailored easily for other biofunctionalization applications. The polymer coatings can be used to sequester the growth factors that the cells themselves are producing during the manufacturing process, thereby mitigating the need for expensive recombinant growth factor supplements. | P07188US, P150079US01
Non-constrictive polymer sheaths as perivascular drug delivery platforms suitable for treating stenosis after open surgery Lian-Wang Guo and
William Murphy
This product will test the efficacy and safety of a perivascular drug delivery platform in a porcine model of restenosis.
ClearView: Lifesaving information when you need it Timothy Hall and
Helen Feltovich
This project focuses on rapid ultrasound-based noninvasive determination of fetal and maternal status in high risk pregnancy at the point of care.
Wound dressing for improved healing W. John Kao The wound dressing provides structure to support new tissue growth and allows for delivery of drugs to minimize pain, eliminate infection or promote healing. | P01328US
Nanomembranes as sound transducers on the ear's tympanic membrane

Max Legally,
Robert Blick and
Burke Richmond
Hearing loss can have a significant negative impact on health and quality of life, and is an emerging worldwide health concern. Current hearing aids are bulky due to their energy supply. The inventors on this project have developed a nanotech-based, wearable and invisible hearing aid that is placed directly on the ear's tympanic membrane, improving hearing and sensing capabilities. This project will build a nanomembrane prototype and demonstrate that nanomembranes have the potential to excite sound waves on the tympanic membrane. | P120327US01
A rapid gradient calibration method for improved MR system performance Alan McMillan and
Samuel Hurley
Although MRI calibration is a routine procedure, current methodologies miss all but gross gradient miscalibration. Errors in calibration can affect the qualitative and quantitative results that are used in disease diagnosis and treatment planning. This project will further the development of a specially designed imaging phantom and analysis software that will provide rapid and robust characterization of errors leading to more complete MRI calibration. | P160026US01
Modular peptide
growth factor
William Murphy The new product works as a coating for orthopedic implants to enhance bone growth at the implant site. | P09202US
Noninvasive quantification of liver iron overload with MRI for diagnosis and treatment monitoring Scott Reeder This method allows for accurate, noninvasive detection and quantification of iron overload of the liver using conventional MRI technology. Accurate measurement of body iron stores is important and a quantitative biomarker is necessary to detect and diagnose iron overload. The biomarker also permits quantitative staging of the severity of iron overload to identify individuals at risk of iron-induced organ damage.
Bioactive cardiac fibroblast-derived extracellular matrix for the treatment of heart failure Eric Schmuck, Amish Raval

This project will validate the small animal safety, toxicology and efficacy of a novel cardiac patch technology that increases the amount of blood the heart is able to pump and provides a new treatment option for congestive heart failure. The patch can be applied during procedures such as bypass surgery and, unlike existing patches, does not require sutures.

Plasma-generated hydroxyl radical protein footprinting J. Leon Shohet and
Michael Sussman
This project concerns development of a device that uses plasma to label proteins in solution, a type of molecular footprinting. The potential reactive sites and three-dimensional structures of the labeled proteins will then be identified and studied using mass spectrometry.
A blood test for predicting colorectal cancer Michael Sussman and
Melanie Ivancic
This project uses mass spectrometry to screen blood proteins to track colon cancer. | P150077US02