Wisconsin Alumni Research Foundation

Technology

Controllable Murine Models of First Pass Metabolism

The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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Christopher Bradfield, Jacqueline Walisser, Tami Thomae | P04330US

Technology

Method to Screen for Novel Antibiotics

The antibiotic vancomycin targets the peptidoglycan-containing bacterial cell wall. Inducible resistance to vancomycin and other glycopeptide antibiotics is becoming a serious health problem, necessit...
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Bernard Weisblum, Robert Giannattasio, Arcady Grenader, Andrew Ulijasz, David Kovalic | P96061US

Technology

Tsp1 -/- Stz Mice, A Model For Diabetes

Effective and non-destructive treatments are needed for diabetic retinopathy, a major cause of blindness in the United States. Thrombospondin1 (TSP1), a matricellular protein that inhibits angiogenesi...
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Nader Sheibani-Karkhaneh, Christine Sorenson | P06036US

Technology

Mouse Model of Glaucoma

Glaucoma is a group of diseases that can result in vision loss and blindness. According to the World Health Organization, glaucoma is the second leading cause of blindness worldwide. Glaucoma causes a...
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Robert Nickells | P06465US

Technology

Model for Stearoyl-CoA Desaturase Activity

Stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids. Inhibitors of SCD may be useful as therapeutic agents for the treatment of diseases such a...
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James Ntambi, Makoto Miyazaki | P06455US

WARF