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WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.
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The gene in C. elegans that encodes the enzyme is called RDE-3. Although its sequence was already known, its polymerase activity was not.
Cost-Effective Isobaric Tandem Mass Tags for High Throughput Quantitative Proteomics and Peptidomics
The reagents consist of a reporter group and a balancing group that are isotopically coded to provide eight compounds with equal molecular weights. The balancing group is designed to provide eight isotopic combinations. The reagents feature an amine reactive group capable of reacting with the molecule to be tagged. Compared to iTRAQ reagents, the eight-plex dimethyl leucine reagents also give rise to high intensity parent and reporter ions, offering enhanced sensitivity and dynamic range for detection and quantitation of low-abundance analytes.
To combine images taken at different times, each of the images is first subdivided into corresponding regions. These are separately registered in rotation and translation, and then combined into a high-resolution image. The process is repeated to create video.
The method can be extended to combine images obtained at different frequencies. This takes advantage of the fact that higher frequencies provide sharper detail closer to the ultrasound machine while lower frequencies are better with distance. Accordingly, acoustic distance is considered when weighting frequency data and combining images.