Explore WARF Inventions and Patents
WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.
Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.
The α/β-peptide mimics (or foldamers) can be tailored to target a variety of different proteins and protein-protein interactions. Given their small size (39 amino acids) relative to full-length Z-domains (59 amino acids), the new peptide mimics are easier to synthesize and modify.
The new amphiphiles, called CAO, DCAO and LCAO, are effective in challenging biochemical systems, such as extraction of delicate photosynthetic superassemblies from native lipid bilayers.
The arrays are prepared using a hydrogel precursor solution containing a polymer and crosslinker. The solution is sandwiched between stenciled SAM layers containing hydrophilic (‘water-loving’) and hydrophobic (‘water-hating’) regions, then polymerized and released.
As a result of the process, the array features hydrophilic spots surrounded and isolated by hydrophobic regions, preventing any mixing of contents. The spots can have any desired shape, size and chemical composition.
In the process, a fresh or frozen sample is stained with DNA-binding fluorescent dye and imaged with a microscope. The brightness of the sperm head is averaged and compared with samples of known fertility.
The entire system consists of a transmitter, a prioritizer, an encoder and an interleaver. The wireless transmitter transmits the symbols. The prioritizer divides received multibit data units into categories of relatively high and low usefulness, and creates mixed multibit data units made up of high and low usefulness bits. The encoder maps the mixed multibit data units to symbols and provides the symbols to the transmitter for transmission. The interleaver and encoder work together to map high usefulness bits to positions within the symbols having lower data error rates.
To detect neutralizing antibodies or other inhibitors of botulinum toxin, the method involves exposing cultured neuronal cells to the toxin and a test sample. The cells are incubated to allow active toxin to cleave an endogenous substrate. Then the cells are harvested and probed to determine how much substrate was cleaved. The more neutralizing antibodies or other inhibitors there are, the less cleavage is observed as compared to the control.
To detect the presence of active neurotoxin, the cultured cells are exposed to a test sample and control samples with known amounts of toxin. The amount of substrate cleavage can be evaluated to determine how much botulinum neurotoxin is present in the test sample as compared to the control samples.