Explore WARF Inventions and Patents
WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.
Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.
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Metformin is attractive because its safety has been established over decades in diabetic patients worldwide. As such, there seem to be few barriers to its clinical implementation as a cancer therapeutic in combination with TRAIL receptor agonists. Metformin is commercially available as Glucophage® or in generic form.
The α/β-peptide mimics (or foldamers) can be tailored to target a variety of different proteins and protein-protein interactions. Given their small size (39 amino acids) relative to full-length Z-domains (59 amino acids), the new peptide mimics are easier to synthesize and modify.
Once the hydrogel array is formed, each of the spots can be exposed to different soluble factors without risk of diffusion.
The new amphiphiles, called CAO, DCAO and LCAO, are effective in challenging biochemical systems, such as extraction of delicate photosynthetic superassemblies from native lipid bilayers.
Varied Monodisperse Oil or Liquid Crystal Emulsion Droplets for Improved Nanoviewing, Sensing and Biosensors
This method is based on templating polyelectrolyte multilayer (PEM) capsules formed by the layer-by-layer adsorption of polyelectrolytes on sacrificial particles. A polymeric shell is formed around a sacrificial particle, such as silica. Then the silica is etched away and the shell is infiltrated with an oil. The shell then can be removed to reveal monodisperse oil or liquid crystal emulsion droplets of a uniform, predetermined size. These droplets could be used as biosensors to detect enzymatic activity or target analytes, such as bacteria or viruses, in a sample.
As the combined fluid mixture heats up during the heat exchange process, L evaporates and the vapor is collected in a tank and condensed back into the liquid phase, leaving the heated fluid comprised mostly of H. As the heated H is cooled after heat exchange, the liquid L is added back into the mixture to prevent H from solidifying as it cools. The high boiling point component of the mixture is useful in increasing the boiling point temperature of the heat transfer fluid and lowering the vapor pressure of the heat transfer fluid at high temperatures. The low freezing point component of the mixture is useful in lowering the freezing point temperature of the heat transfer fluid, ensuring that it does not solidify during the temperature cycle.
The system of the invention includes a vessel for containing the heat transfer fluid, a heat source, an outlet for removing some of L as temperature increases during the cycle and an inlet for re-adding L as temperature decreases during the cycle.
A subject receives a dose of hyperpolarized imaging compound. MR image data is acquired from the subject according to a k-space sampling trajectory that spatially oversamples to encode both spatial and spectral frequency information at the oversampled points. The MR image data then can be reconstructed into the different image types using a model-based reconstruction technique and prior knowledge of the chemical species associated with the compound.