Explore WARF Inventions and Patents
WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.
Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.
Visit our subscription center to sign up for our monthly email updates and learn when new WARF technologies become available for licensing.
The researchers found that a class of compounds called acid sphingomyelinase inhibitors can be used to fight retinal disorders associated with abnormal accumulations of lipofuscin (a cellular waste product), cholesterol or increased inflammation. One such inhibitor, generic name desipramine, is currently sold on the market as an antidepressant. Other acid sphingomyelinase inhibitors also may be suitable.
The molecules inhibit the growth of microorganisms that depend on UGM to incorporate Galf residues. They also diminish the virulence of pathogenic microorganisms, such as M. tuberculosis, M. smegmatis and Klebsiella pneumonia, that rely on UGM.
The researchers have found that in low doses the drug provides an optimal amount of tonic inhibition that restores function and reduces symptoms in a mouse model. The drug may be particularly useful for treating young patients whose condition is characterized by a reduction in tonic inhibition.
Metformin is attractive because its safety has been established over decades in diabetic patients worldwide. As such, there seem to be few barriers to its clinical implementation as a cancer therapeutic in combination with TRAIL receptor agonists. Metformin is commercially available as Glucophage® or in generic form.
To harvest energy, incident photons excite the electrons within the semiconducting layer and holes in the electrode to generate electron-hole pairs via the photovoltaic effect of solar energy being absorbed. The electrons attract ions to the cathode electrode, creating a concentration gradient across the device. The device is charged using this process until a saturated electric potential difference is reached. The diffusion force of the ions and electric field are counter-balanced and maintain a stable electrical double layer across the two electrodes.
The virtual substrates comprise several layers. The underlying GaAs substrate has a certain lattice constant. Over this, an MBL is grown via the HVPE process. The MBL is sufficiently thick to avoid warping. It is compositionally graded so that its lattice constant matches the underlying substrate, but transitions to a different lattice constant at its surface where the semiconductor device will be grown.
The MBL surface can be polished and reused to grow multiple semiconductor devices.