Through Technologies

Explore WARF Inventions and Patents

WARF Technologies

WARF’s portfolio of more than 1,600 patented technologies covers a wide range of categories, including analytical instrumentation, pharmaceuticals, food products, agriculture, research tools, medical devices, pluripotent stem cells, clean technology, information technology and semiconductors.

Information summaries, which describe each technology and its applications, benefits, inventors and patent status, can be downloaded, printed and shared by clicking on the technology category links to the left on this page.

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New Inventions

New System for Producing Fungal Secondary Metabolites

UW–Madison researchers have developed a new system for producing fungal secondary metabolites using test plasmids and a genetically modified strain of Aspergillus nidulans (TPMW2.3). The strain begins producing secondary metabolites when a gene promoter in the plasmid is triggered by culture conditions. This allows researchers to induce or repress production.

Peptide Mimics Last Longer, Target Protein-Protein Interactions

UW–Madison researchers have developed modified Z-domain peptides that last longer in vivo while retaining strong binding properties. The researchers removed one of the helices and stabilized the remaining two with a disulfide bond. They substituted some residues with alpha and beta amino acid residues; the latter helps resist degradation by proteolytic enzymes.

The α/β-peptide mimics (or foldamers) can be tailored to target a variety of different proteins and protein-protein interactions. Given their small size (39 amino acids) relative to full-length Z-domains (59 amino acids), the new peptide mimics are easier to synthesize and modify.

New Amphiphiles for Manipulating Membrane Proteins

UW–Madison researchers have developed improved amphiphiles for solubilizing, isolating and characterizing membrane proteins. They can be prepared from cholic acid, deoxycholic acid and lithocholic acid, which are steroids found in bile.

The new amphiphiles, called CAO, DCAO and LCAO, are effective in challenging biochemical systems, such as extraction of delicate photosynthetic superassemblies from native lipid bilayers.

Superabsorbent, Sustainable Aerogels

UW–Madison researchers have developed organic aerogels with excellent absorbent properties. They are made by combining a water soluble polymer and cellulose nanocrystals/nanofibers (CNFs) derived from biomass. The polymer, such as PVA (polyvinyl alcohol), is cross-linked to form a gel and then water is removed by freeze-drying. The surface of the aerogel is coated with an organosilane, making it highly water repellent and superoleophilic (‘oil loving’).

Low-Cost Mastitis Test Speeds Detection

UW–Madison researchers have developed a new test that takes less than two hours and can be used in the field or lab to simultaneously detect the eight most important mastitis pathogens. The assay works on DNA extractions from milk or other samples (e.g., blood or environmental) using loop-mediated isothermal amplification (LAMP) that can be performed using only the kit and a heat block.

The test involves a rapid DNA extraction method (~ 35 minutes) followed by a 47-minute running time. The researchers developed a ‘master mix’ reaction solution for all eight pathogen-specific primers.

The new assay can test for: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus dysgalactiae, Streptococcus uberis, E. coli, Klebsiella pneumonia, coagulase-negative Staphylococci and Mycoplasma bovis. The result is a simple yes/no.
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New Patents

Click Chemistry-Based Multi-Enhanced Biomaterials Help Heal Wounds

The UW–Madison researchers have now adapted “click chemistry” in lieu of an external energy source to form the sIPNs. This allows a wider variety of sensitive bioactive molecules, including therapeutic cells, to be entrapped within the sIPNs, enhancing the clinical applicability of the technology.

Selective Conversion of Lignin into Simple Aromatic Compounds

UW–Madison researchers have developed a metal-free, aerobic oxidation method that selectively transforms the benzylic alcohol in lignin to the corresponding ketone. The process uses a nitric acid (HNO3) catalyst combined with another Brønsted acid. The reaction leaves unchanged at least a portion of unprotected primary aliphatic alcohols in the lignin or lignin subunit.

The reaction may be carried out in any suitable polar solvent and in the presence of additional reagents including TEMPO and derivatives.

Method and Electrocatalyst to Efficiently Produce Hydrogen Fuel over a Broad, Acidic pH Range

UW-Madison researchers have developed an improved method for generating oxygen and hydrogen with a cobalt-oxide electrocatalyst that uses fluorophosphate or a similar anion electrolyte as the electrolytic buffer in the electrolysis reaction. Using this method, an anode and a cathode are placed in an aqueous solution containing water, a cobalt cation and the anion electrolyte. Then an external source of energy (potentially derived from solar, wind or other renewable energy) drives the electrolysis reaction to generate oxygen and hydrogen. Alternatively, a catalyst containing cobalt, oxygen and the anion electrolyte can be deposited on the anode of the electrochemical cell prior to electrolysis in cobalt-free conditions.

This cobalt-oxide catalyst enables efficient oxidation of water at room temperature over a more favorable pH range. The reduction in overpotential makes it easier and less expensive to split water into hydrogen and oxygen, while the expanded pH range allows water oxidation to be coupled with desirable reactions such as reduction of carbon dioxide at the cathode. In addition, the electrolyte buffers are compatible with conventional materials used in electrochemical cells. The hydrogen gas output of this process can be collected and used as an alternative fuel source or as feedstock for conversion into other fuels or materials. The oxygen gas can be collected, dried and used for any process requiring pure oxygen.
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