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319 Results for 'Research Tools'
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Technology
Immortalized Cells from the Mouse Urogenital Sinus and Adult Mouse Prostate
No well-characterized prostate stromal cell lines currently exist.
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Wade Bushman | P03405US
Technology
Monoclonal Antibodies Specific for the Cytoplasmic Gamma-actin Isoform
The six mammalian actin genes encode a highly conserved family of cytoskeletal protein isoforms important in cell structure, mechanical stability, and motility. Actin isoforms exhibit tissue-specific ...
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James Ervasti, Laurin Hanft | P05366US
Technology
Cell Line Stably Expressing Human Cardiac Ion Channel Common Polymorphism, K897T
The human either-a-go-go related gene (HERG1 or KCNH2) potassium channel is critical to maintaining normal cardiac rhythm. Because unintended block of HERG channel activity by drugs can cause long QT ...
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Craig January, Blake Anson, Corey Anderson, Brian Delisle | P05413US
Technology
Super Bac 1 - An Inducible Vector With Shuttle Capability
Because they retain large DNA inserts over many generations, bacterial artificial chromosomes (BACs) are popular vectors for genetic and expression analyses of genomic DNA libraries; however, their us...
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Jo Handelsman, Robert Goodman, David Mann | P01167US
Technology
Promoter-Trap Plasmid for Identifying Promoters
Promoters are genetic regulatory elements that drive gene expression in cells under certain conditions. One way to identify promoters is to use a promoter-trap vector, which is a plasmid containing a ...
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Jo Handelsman, Anne Katherine Dunn | P03159US
Technology
Janthinobacterium lividium Isolates from Alaskan Soil
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Jo Handelsman, Patrick Schloss, Amy Klimowicz | P06058US
Technology
Collection of Bacterial Isolates from Alaska That Do Not Grow at Temperatures at or Above 37ºC
Microorganisms adapted to grow in exceptionally harsh environments, such as hot springs and arctic soils, are a potentially vast source of novel metabolic processes, antibiotics, enzymes and other pro...
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Patrick Schloss, Jo Handelsman | P06059US
Technology
A Mutation in the Rat Adenomatous Polyposis Coli Gene within the Human Mutation Hotspot Region
Humans with mutations in the Adenomatous Polyposis Coli (APC) gene develop hundreds or even thousands of adenomas in the colon, which often lead to colorectal cancer. Mouse models of human intestinal ...
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William Dove, Michael Gould, Lawrence Kwong, James Amos-Landgraf, Jill Haag | P06116US
Technology
Exploring Natural Products from Actinobacteria Symbionts Associated with Animals and Plants
Actinomycetes, which are Gram-positive filamentous bacteria, produce the majority of known antibiotics. Fungus-growing Attine ants engage in a mutualistic association with actinomycetes to defend thei...
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Cameron Currie | P07080US
Technology
Light-Directed DNA Synthesis Using Inverse Capping for Error Reduction
Because conventional DNA sequencing using electrophoresis is laborious and time consuming, alternative approaches, such as those using microarrays, have been developed. Photolithographic techniques ar...
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Franco Cerrina, Changhan Kim | P06072US
Technology
A Saturating Population of Insertionally Mutagenized Arabidopsis thaliana Plants
Functional genomics involves identifying the function of all genes within a sequenced genome. Knockout mutants may be used to identify the in situ function of any gene, without making assumptions abou...
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Michael Sussman, Richard Amasino | P98227US
Technology
Tagged RNA Polymerases and Method for Producing Them
Much of the research on RNA transcription is focused on the action of RNA polymerases. Thus, improved methods for purifying and characterizing RNA polymerase greatly enhance studies of transcription. ...
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Robert Landick, Rachel Mooney | P98111US
Technology
HERG-1 Transfected HEK 293 Cell Line B
Re-polarization of the cardiac action potential, which plays a critical role in maintaining normal cardiac rhythm, occurs mainly due to the action of potassium ion (K+) currents in the heart. The most...
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Craig January, Zhengfeng Zhou, Qiuming Gong, Gail Robertson, Blake Anson, Matthew Trudeau, Corey Anderson | P04289US
Technology
Varied Monodisperse Oil or Liquid Crystal Emulsion Droplets for Improved Nanoviewing, Sensing and Biosensors
Controlled micrometer-scale oil droplets have applications in nano-materials, meso-materials, responsive materials, optical materials, filters, sensors and opto-electronic technologies. Emulsion dro...
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Nicholas Abbott, Frank Caruso, Jugal Gupta, Sri Sivakumar | P08136US
Technology
Microfluidic Device for Capturing and Analyzing Rare Cells, Including Circulating Tumor Cells
Circulating tumor cells (CTC) are an important area of cancer research. They could provide clinically relevant information about a patient’s prognosis. However, these cells are extremely rare (r...
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David Beebe, Jay Warrick, Erwin Berthier | P100069US01
Technology
Collection of Drosophila Mutants with Neurodegenerative Effects
Few treatments for neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, have been discovered. In many cases, the molecular basis for neurodegeneration remains unknown...
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Barry Ganetzky, Michael Palladino, Robert Kreber | P02000US
Technology
Plasma-Enhanced Functionalization of Inorganic Oxide Surfaces
Bioactive surfaces created by binding biomolecules to the surface of inorganic substrates are used in many bioassays, biosensors, and other devices. One common approach to functionalizing surfaces so ...
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Ferencz Denes, Sorin Manolache, Jason Helgren, Max Lagally, Bradley Larson | P04163US
Technology
Mutated Tn5 Transposase Proteins and Their Uses
The low mobility of bacterial transposons, such as Tn5, makes it difficult for researchers to detail the molecular transposition process and to exploit transposition for uses such as the development o...
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William Reznikoff, Richard Gradman | P03381US
Technology
Multidimensional Spectrometer
Over the last eight years, academic researchers have been developing a new set of spectroscopic techniques that are multidimensional versions of visible and infrared spectroscopies, such as two-dimens...
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Martin Zanni, Niels Damrauer | P07420US
Technology
Fluorescent Assays with Improved Sensitivity
Fluorescent molecules are essential tools for many scientific applications, including basic research, drug development, and disease diagnosis.
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Ronald Raines, Sunil Chandran, Timothy Glass, Luke Lavis | P03254US
Technology
Using UV Light to Functionalize Metal Oxides for Use in Biosensors, Solar Cells and Other Devices
Functionalized substrates have commercial applications ranging from biosensors to energy conversion devices such as solar cells. Biosensors rapidly detect the presence of target biomolecules based o...
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Robert Hamers, Bo Li, Elizabeth Landis, Ryan Franking | P09033US
Technology
Device That Uses Dielectrophoresis to Transport and Position Individual Particles/Cells for Analysis
Dielectrophoresis is a technique for gathering particles that uses an electric field to induce an electrical polarization in an uncharged object. The electrical polarization then interacts with variat...
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Robert Hamers, Joseph Beck | P05149US
Technology
Phytochrome-Based Fluorophores with Strong Fluorescence in the Red/Far-Red Region
Several fluorescent reporter molecules, such as the Green Fluorescent Protein (GFP), are available as research tools to monitor gene activity and protein distribution within cells. However, currentl...
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Andrew Ulijasz, Junrui Zhang, Katrina Forest, David Anstrom, Jeremiah Wagner, Richard Vierstra | P07413US
Technology
Cell Line Stably Expressing KvLQT1 and minK
One of the key potassium channels in the heart is formed by the co-assembly of protein products from the KvLQT1 (KCNQ1) and minK (KCNE1) genes, which produce the slowly activating delayed rectifier po...
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Craig January, Sridharan Rajamani, Corey Anderson | P03073US
Technology
Methods of Using Redox-Active Surfactants to Control Polymer Interactions
Cationic lipid-mediated delivery of nucleic acids and proteins may replace virus-mediated transfection of exogenous DNA for many applications. However, current lipid-based carriers provide limited con...
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Nicholas Abbott, David Lynn, Yukishige Kondo, Christopher Jewell, Melissa Hays | P05276US