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319 Results for 'Research Tools'
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Technology
Electronically Activated Strained Alkynes
R1 and R2 are hydrogen or C1 to C12 linear or branched alkyl; R3 is hydrogen, C1 to C12 linear or branched alkyl, or nitrogen protecting groups; X is oxygen or nitrogen; and when X is oxygen, R4 is ab...
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Jennifer Schomaker, Eileen Burke | P170043US02
Technology
Planar High-Speed Molecule Sequencer
A molecule sequencer uses a planar nanochannel for aligning molecules to flow past impedance interrogation electrodes mounted across the channel for rapid sequencing. The electrodes may be fixed to th...
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Robert Blick, Abhishek Bhat, Paul Gwozdz | P180156US01
Technology
System And Process For Validating, Aligning And Reordering One Or More Genetic Sequence Maps Using A
A method and system are provided for comparing ordered segments of a first DNA restriction map with ordered segments of a second DNA restriction map to determine a level of accuracy the first DNA map ...
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David Schwartz, Marco Antoniotti, Bud Mishra, Tom Anantharaman, Salvatore Paxia | P04027US
Technology
Hydrogel Compositions For Use In Cell Expansion And Differentiation
Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiatio...
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William Murphy, Matthew Parlato, Ngoc Nhi T. Le, James Molenda | P150263US01
Technology
Hydrogel Compositions For Use In Promoting Tubulogenesis
Hydrogel Compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to rapidly screen substrate components for influencing cell ...
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William Murphy, Eric Nguyen, Michael Schwartz, Hamisha Ardalani, Matthew Zanotelli, Matthew Parlato, David Belair, William Daly, Ngoc Nhi T. Le, Stefan Zorn | P140314US02
Technology
System And Method For Characterizing Ions Using A Superconducting Transmission Line Detector
A system and method for characterizing incident ions are provided. The method includes positioning a transmission line detector to receive incident ions, the transmission line detector comprising a su...
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Robert McDermott, Joseph Suttle | P150094US01
Technology
Electronically Activated Strained Alkynes
Compounds of Formula I: [Image Omitted] wherein: R1 and R1′ are independently selected from hydrogen, halogen, C1-to-C12 linear or branched hydroxyalkyl, C1-to-C12 linear or branched halo-alkyl, ...
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Jennifer Schomaker, Eileen Burke | P170043US03
Technology
Compositions And Methods Of Using Differentiated Cells Sensitized To Botulinum Neurotoxin
Differentiated cholinergic cells having motor neuron-like morphology and increased sensitivity to botulinum neurotoxin are provided herein. Methods of using such differentiated cells for detecting neu...
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Eric Johnson, Regina Whitemarsh, Sabine Pellett | P130013US02
Technology
Using Liquid Crystal To Detect Endotoxin In The Presence Of One Or More Potential Masking Agents
Devices and methods for using changes in the configuration of micrometer sized dispersed liquid crystal domains to detect or quantify analytes in a test sample, including endotoxin lipopolysaccharide ...
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Nicholas Abbott, Abhijit Dan | P160072US02
Technology
Methods And Systems For Transmission And Detection Of Free Radicals
The present disclosure provides systems and methods for characterizing the interaction of free radicals with various materials and the use of known interactions to isolate free radical generation from...
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J. Leon Shohet, Michael Sussman, Faraz Choudhury, Benjamin Minkoff, Grzegorz Sabat, Joshua Blatz | P170004US02
Technology
Antibodies Targeting Glioblastoma Stem-Like Cells And Methods Of Use Thereof
The present invention provides antibodies that target glioblastoma stem-like cells and methods and kits for their use.
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Eric Shusta, Michael Zorniak, Paul Clark, Yongku Cho, Benjamin Umlauf, John Kuo | P180018US02
Technology
Petri Dish With Single-Handed Lid Connection And Removal
A petri dish has interlock features between the lid and dish that allow single-handed engagement of the lid with the dish by rotation, so that the lid and dish may be raised by grasping only the lid w...
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Aleksandar Wood, Harpreet Singh | P190121US02
Technology
A Method To Determine The Throughput Speed Of A Pore
A method (100) can be provided to determine the throughput speed v of at least one pore (1), comprising: • feeding (110), using a driving force F, a filiform calibration element (2) through the pore...
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Robert Blick, Paul Gwozdz, Abhishek Bhat | P160202US02
Technology
System And Method For En Masse Patterning Of Molecule Structures
Devices, systems, and methods for en masse patterning of nucleic acid molecule structures are disclosed. The devices can include microchannels and nanoslits. The microchannels and nanoslits can be con...
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David Schwartz, Kristy Kounovsky-Shafer, Juan Hernandez-Ortiz, Konstantinos Potamousis, Kyubong Jo, Juan DePablo, Theo Odijk | P170209US02
Technology
A Ratiometric Biosensor To Measure Intracellular Nadh/Nad+ Redox
Described herein is a redox biosensor system for measurement of NADH/NAD+ ratio including a host strain or cell-free system including first and a second expression cassette; the first expression casse...
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Srivatsan Raman, Yang Liu, Robert Landick | P190071US02
Technology
Sensor For Cyanuric Acid Detection
A cyanuric acid-responsive biosensor includes a host strain or cell-free system including a first and a second expression cassette; the first expression cassette including, in operable communication, ...
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Srivatsan Raman, Xiangyang Liu | P180322US02
Technology
Method To Enhance Screening For Homologous Recombination In Genome Edited Cells Using Recombination-Activated Fluorescent Donor Delivery Vector
Constructs, vectors, and methods for enhancing homology directed repair using the CRISPR/Cas9 gene editing platform are disclosed.
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Mark Burkard, David Thompson | P180200US02
Technology
Vector For Gene Silencing And Replacement And Methods Of Use Thereof
An expression cassette for gene silencing and replacement, including, in operable communication, a promoter, an expression attenuator, a nucleotide sequence encoding a gene for a replacement target pr...
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Erik Dent, Matthew Millette | P180170US02
Technology
Systems And Methods For Identifying Sequence Information From Single Nucleic Acid Molecule Measurements
Systems and methods for identifying sequence information from measurements made on single nucleic acid molecules are disclosed. The systems and methods can include binding portions of nucleic acid mol...
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David Schwartz, Subhrangshu Nandi, Michael Newton | P180056US02
Technology
Lesion Volume Measurements System
An apparatus for measuring lesion volume, for example, in laboratory animals, provides a mirror box allowing a camera to simultaneously acquire profiles of the lesion along at least two crossing axes ...
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Randall Kimple, Junzhou Chen, Hunter Higby, Ryan Wisth, Kyuhyun Lee, Jeremy Rogers | P190262US02
Technology
Systems And Methods For Fully Automated Protein Engineering
Systems and methods for protein engineering. The systems include a sequence testing subsystem and a machine learning subsystem. The sequence testing subsystem is configured to express proteins and tes...
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Philip Romero, Bennett Bremer, Jacob Rapp | P190269US02
Technology
HLF-VC1 Master Cell Bank for Vaccine Development
FDA-qualified cell lines must be used for virus production for human vaccines. There are relatively few of these lines available and several (WI-38, MRC-5) used for virus production are becoming senes...
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James Gern | P160170US01
Technology
Artificial Transcription Factors and Uses Thereof
Transcription factor expression can profoundly alter the transcriptional dynamics of a cell, even inducing the transition to a new cell fate. Four transcription factors – Oct4, Sox2, Klf4, and c-Myc...
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Aseem Ansari, Asuka Eguchi | P160383US02
Technology
Nanocapsule Delivery System For Ribonucleoproteins
With the explosion of interest in using the CRISPR/Cas9 system for gene editing, there is a strong focus on developing tools for delivering the CRISPR machinery safely and efficiently into cells. Exis...
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Shaoqin Gong, Krishanu Saha, Guojun Chen, Amr Abdeen, Yuyuan Wang, Ruosen Xie | P170376US02
Technology
Nuclease Inhibitors and Methods for Their Use
Biochemical research and biotechnology rely on nucleic acids; however, nucleic acids frequently encounter nucleases that can negatively affect experiments. Although nuclease inhibitors are often used ...
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Ronald Raines, Bryan Smith, David Lynn, Matthew Soellner | P05096US