Wisconsin Alumni Research Foundation

Technology

Inhibitors Of Collagen Prolyl 4-Hydroxylase

The invention provides biheteroaryl dicarboxylates and esters, and salts thereof which are useful generally as modulators of CP4H activity, more particularly as inhibitors of CP4H, or further as chemi...
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Ronald Raines, James Vasta | P150092US02

Technology

Compositions And Methods For The Inhibition Of Fibrosis

Described herein is a mono-end PEGyated functional upstream domain (FUD), pharmaceutical compositions, and its use to inhibit fibrosis such as organ fibrosis, idiopathic pulmonary fibrosis and fibrosi...
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Bianca Tomasini-Johansson, Glen Kwon, Pawel Zbyszynski, Nathan Sandbo, Ksenija Bernau | P180076US02

Technology

Skin Whitening Agent(s)

The global cosmetics industry is a $460 billion dollar market with the skin whitening sector valued at $381 million in 2014. This growing market is projected to increase at a CAGR of 11.7%, reaching $...
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Cheng-chen Huang, Aaron Monte | T140007WO01

Technology

Modified Retinoid Compounds with Reduced Toxicity

Orally administered retinoic acid isomers are used to treat many disorders; however, they cause serious side effects including weight loss, inanition, eye encrustation, bone loss, mucocutaneous toxici...
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Margaret Clagett-Dame, Hector DeLuca, Sumithra Gowlugari | P02381US

Technology

Hyperstable Collagen Mimics

Collagen, the most abundant protein in vertebrates, serves as the fundamental structural protein for vertebrate tissues. Collagen is a fibrous protein consisting of three polypeptide chains that fold ...
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Ronald Raines, Jonathan Hodges | P03226US

Technology

Use of Neuropeptides for Ligament Healing

Ligament healing is a complex problem that is influenced by inflammatory cell responses, extracellular matrix remodeling and chemical mediators. Healing potential varies widely among ligaments, with t...
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Ray Vanderby, Kelley Grorud | P04056US

Technology

Stable Collagen Mimics

Collagen, the most abundant protein in vertebrates, provides structure for tissues and plays a key role in wound healing. In connective tissue, individual collagen molecules are wound together in tigh...
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Ronald Raines, Matthew Shoulders, Jonathan Hodges | P06406US

WARF