Wisconsin Alumni Research Foundation

Technology

Vaccines Comprising Mutant Attenuated Influenza Viruses

The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant ...
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Yoshihiro Kawaoka, Shinji Watanabe, Tokiko Watanabe | P100251US02

Technology

Novel Adjuvant For Animal And Human Vaccines

Quil-A chitosan spherical nanostructure complexes as well as methods of making and using such complexes are disclosed herein. Also provided are Quil-A chitosan spherical nanostrucutres loaded with one...
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Adel Talaat, Shaswath Chandrasekar | P190189US02

Technology

Humanized Cell Line

A mammalian or avian cell line that expresses high levels of human influenza virus receptors is provided. In one embodiment, the cell line supports human influenza virus, e.g., human A/H3 influenza vi...
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Yoshihiro Kawaoka, Kosuke Takada, Masaki Imai | P180301US03

Technology

Influenza Variant Grows Well in CHO Cells

Vaccines against influenza and other viruses can be grown in Chinese Hamster Ovary (CHO) cells. Problematically, an influenza virus that is made by combining H1N1 and PR8 strains, and that is recommen...
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Yoshihiro Kawaoka, Makoto Ozawa | P100246US02

Technology

Neuraminidase-Deficient Live Influenza Vaccine

Influenza infects up to 20 percent of the world’s population every year, causing 500,000 deaths and costing tens of billions of dollars in medical expenses. Influenza A virus, which causes pandemics...
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Yoshihiro Kawaoka, Masato Hatta | P07044US

Technology

Vaccine for Fungal Infections

There are no commercial vaccines against fungi. Infections like aspergillosis and Valley Fever can be life-threatening, particularly in immune-compromised patients. These patients also are more vulner...
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Bruce Klein, Theodore Brandhorst, Thomas Sullivan, Marcel Wuethrich | P130116US02

Technology

Potential for Vaccine Against Johne’s Disease

Johne’s disease, or paratuberculosis, is a chronic and usually fatal wasting disease that is found worldwide and impacts more than half of the dairy herds in the U.S. alone. It costs the ruminant in...
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Adel Talaat | P130200US02

Technology

Safer Ebola Virus and Vaccines

Ebola is the deadliest virus on earth. It has caused death in 90 percent of cases during some outbreaks, afflicting human and great ape populations in tropical Africa. The virus is highly contagious i...
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Yoshihiro Kawaoka, Peter Halfmann, Jin Hyun Kim | P07377US02

Technology

Safer Influenza Vaccine from Replication-Knock Out Virus

Influenza viruses instigate annual global epidemics. The first influenza pandemic in 40 years occurred during the 2009-2010 season, when a novel H1N1 strain emerged and spread worldwide. The United St...
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Yoshihiro Kawaoka, Gabriele Neumann, Makoto Ozawa | P110003US02

Technology

Plasmids Encoding Avian Influenza Genes

Avian influenza causes significant economic losses for poultry producers worldwide and can be transmitted to humans and other mammals. The surface glycoproteins hemagglutinin (HA) and neuraminidase (N...
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Yoshihiro Kawaoka | P06123US

Technology

High Titer Recombinant Influenza Viruses for Vaccines

Influenza is caused by the eight-segmented influenza virus. Vaccines can be used to prevent influenza, but traditional methods for producing influenza vaccine are slow and cumbersome. To generate reco...
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Yoshihiro Kawaoka, Taisuke Horimoto, Shin Murakami | P06370US

WARF