Wisconsin Alumni Research Foundation

Technology

Multidimensional Imaging with Improved Contrast

Studying molecular properties in complex chemical and biological samples, including live cells, requires sufficient spatial resolution and contrast between different substructures. To achieve enhanced...
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John Wright, Erin Boyle | P140021US02

Technology

Micromachined Scanning Thermal Probe

Scanning thermal probes hold promise for many applications, including high-resolution temperature mapping (e.g., for ULSI circuit diagnostics), topographical mapping, photothermal absorption spectrosc...
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Yogesh Gianchandani, Mo-Huang Li, Julius Wu | P01026US

Technology

More Efficient Semiconductor Lasers

Quantum cascade lasers (QCLs) are semiconductor lasers that provide light in the mid- and far-infrared wavelength ranges. They are designed so that the generated light is transverse-magnetic (TM) pola...
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Luke Mawst, Dan Botez, Thomas Earles, Jeremy Kirch, Christopher Sigler | P140047US01

Technology

Microscope Probe Having an Ultra-Tall Tip

Atomically sharp micro-fabricated tips are used in atomic force microscopy (AFM) for scanning near-field microwave microscopy (SNMM) to create an image of the tiny topography on or under a surface. Th...
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Daniel van der Weide, Yaqiang Wang | P06244US

Technology

Bioreversible Protein Esterification

Proteins contain carboxyl groups. These charged groups make it difficult for any protein to enter a human (or other eukaryotic) cell. Modifying proteins to enter cells could revolutionize medicine, e....
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Ronald Raines, Nicholas McGrath | P130148US02

Technology

Strain-Tunable Light Emitting Diodes Using Germanium

Germanium (Ge), a group-IV semiconductor material, is crucial to many established and potential technologies. In optoelectronics, Ge has been used as a photodetector material for on-chip data distribu...
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Max Lagally, Jose Sanchez Perez | P140041US01

Technology

Microwell Moat Prevents Spillover

The ability to study single cells has become indispensable, helping researchers identify characteristics and behaviors otherwise hidden using population averages. By obtaining multiple measures per ce...
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Jay Warrick, John Yin, Stephen Lindsay | P120353US01

Technology

Tuning Optical Microcavities

A whispering gallery mode (WGM) is a type of electromagnetic wave that travels around a concave surface. Such waves can propagate at the edge of a very small structure called an optical microcavity. W...
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Randall Goldsmith, Kevin Heylman | P140153US01

Technology

Compact Spectrometer

Spectrometers are optical instruments used to measure light. They work by detecting spectral lines and measuring their wavelength or intensity. Spectrometers have many applications, including telecomm...
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Zongfu Yu | P140145US01

Technology

Faster Gas-Phase Protein Sequencing

Determining the amino acid sequence of any given protein or polypeptide is a formidable task. The first major technology to emerge for this purpose was the Edman degradation method, which sequences a ...
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Lloyd Smith, Michael Westphall, Xiaoyu Chen, Brian Frey | P04178US

Technology

Monitoring Tissue Fluorescence in Bright Light

Intrinsic and extrinsic fluorescent markers can help surgeons target and rapidly identify tumorous tissue. The signals given off by these markers are relatively faint and normally viewed with a fluore...
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Thomas (Rock) Mackie, Adam Uselmann, Andreas Velten, Surendra Prajapati, Kevin Eliceiri | P130298US01

Technology

An Enhanced Method of Embedding Thin Film Sensors

Surface mounted and exposed sensors are used in objects commonly found in a modern society that range from simple temperature monitors to complex airbag ejection systems. But sensors located on the su...
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Xiaochun Li, Xudong Cheng, Arindom Datta | P07193US

Technology

Dielectric Sensor for Stress and Strain Detection

Load bearing structures experience stresses and/or strains that deform the material from which they are made. Regardless of a building component’s size, exposure to or tolerance for stress and s...
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Yuri Shkel, Ho Young Lee, Yiyan Peng | P08252US

Technology

More Flexible Microlens Assembly

‘Variable-focus’ lenses are lenses that have adjustable focal lengths. Liquid-based, miniaturized lenses of this type are useful in photonics, display systems and biomedical tools. However...
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Hongrui Jiang, Chenhui Li | P120362US01

Technology

Electrodes with Low-Cost Replaceable Tips

Electrodes routinely are used in electrochemical sensing, fuel cells, batteries and numerous other applications. Critically, the surface of an electrode must be clean before sensing elements can be at...
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Sundaram Gunasekaran, Jiang Yang | P120016US02

Technology

Ultra-Efficient Continuous Monitoring of Sensors

Tracking emissions, sensing earthquakes and monitoring patient brain waves are just a few of the applications that rely on changing, real-world information. In typical systems, sensors pass on raw dat...
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Mikko Lipasti, Atif Hashmi, Andrew Nere, Giulio Tononi | P130049US01

Technology

Ultrasonic Welding with Real-Time Quality Control

In ultrasonic welding, work pieces are clamped between a horn and anvil and then joined using high-frequency vibration energy. Friction and heat between the surfaces causes them to soften and meld tog...
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Xiaochun Li, Hongseok Choi, Hang Li, Wayne Cai, Jeff Abell, Jingzhou Zhao | P120081US01

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