Wisconsin Alumni Research Foundation

Technology

Animal Model of Brittle Bone Disease

Osteogenesis imperfecta (OI) or brittle bone disease is an incurable genetic disorder that causes fragile bones and a lifetime of breaks and fractures. Recently, mutations in the gene for bone morphog...
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Daniel Greenspan, Se-Jin Lee | P160036US01

Technology

Wisconsin Miniature SwineTM for Biomedical Research

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P130271US01

Technology

Wisconsin Miniature SwineTM for Cardiovascular Research

Rodents and other small animals are extensively used as models to study human health and disease, but there are increasing concerns about their relevance. Research funding and regulatory agencies are ...
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Jess Reed, Christian Krueger, Dhanansayan Shanmuganayagam, Thomas Crenshaw, Jamie Reichert, Joan Parrish | P140228US01

Technology

Mouse Model for Mania

Presently, there are no good rodent models for mania, which is a critical component of bipolar disorder. The most commonly used approach is to inject normal mice with amphetamines to produce hyperacti...
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Stephen Gammie | P100188US01

Technology

Feline Model of Glaucoma

Glaucoma, the second leading cause of blindness in the United States, is an eye disease that results in optic nerve damage and loss of vision. However, few large-eyed models of spontaneous glaucoma ex...
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Gillian McLellan, Matthew Ellinwood, Markus Kuehn | P110032US01

Technology

A Transgenic Mouse Model for Human Liver Disease

Many of those currently on waiting lists for liver transplants are victims of liver failure associated with hepatocyte toxicity. This toxicity can be caused by alcohol abuse, or by prescription or non...
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Eric Sandgren, Kristin Braun, Teresa Weglarz, Jay Degen | P01325US

Technology

Laboratory Rat Procedural Techniques Training DVD and Manual

When using live vertebrate animals, principal investigators for any activity supported by a Public Health Service (PHS) agency, such as the FDA, NIH or CDC, must comply with the PHS policy on Humane C...
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John Bogdanske, Beth Schiffman, Scott Hubbard-Van Stelle, Margaret Riley | P09138US

Technology

Controllable Murine Models of First Pass Metabolism

The liver detoxifies many of the drugs and toxins in blood, which poses a problem in drug development and testing because drugs are rapidly cleared from the system. In the mammalian fetus, the liver i...
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Christopher Bradfield, Jacqueline Walisser, Tami Thomae | P04330US

Technology

Assay to Detect Viral Uncoating

During or shortly after a retrovirus particle enters a host cell, the particle undergoes a process known as “uncoating,” where the viral genome is freed from the viral envelope and becomes...
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John Young, Shakti Narayan | P04156US

WARF